Fabrication and characterization of PVA/Collagen/Gelatin scaffold for microtia reconstruction.

IF 2.5 4区医学 Q3 ENGINEERING, BIOMEDICAL

Journal of Biomaterials Applications Pub Date : 2025-08-25 DOI:10.1177/08853282251374428

Amaliya Rasyida, Nabila Firdausi Nuzula, Sigit Tri Wicaksono, Indri Lakhsmi Putri, Hosta Ardhyananta, Yung-Hsin Cheng

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引用次数: 0

Abstract

Polyvinyl alcohol (PVA) is commonly used as a scaffold in tissue engineering applications. However, PVA has limitations in achieving mechanical properties that are suitable for natural cartilage. Collagen and gelatin are natural polymers with biocompatible, biodegradable properties, and low immune reactions. In the study, PVA/collagen/gelatin (PVA/Coll/Gel) were developed for microtia reconstruction. The effects of adding collagen of 5, 10, 15, 20, and 25% on the X-ray diffraction (XRD), Fourier-transform infrared spectroscopy, microstructure, elastic modulus, and swelling properties of PVA/Coll/Gel were characterized and optimized. The results of the XRD analysis showed that the phase transitioned from semi-crystalline to amorphous in the PVA/Coll/Gel scaffold containing 20% and 25% collagen. The developed composites with 15%, 20% and 25% collagen have the similar mechanical strength to that of human auricular cartilage. The PVA/Coll 5%/Gel scaffold with the largest pore size (∼66.47 μm) exhibits the highest swelling rate compared to the other groups. The results suggested that PVA/Coll/Gel scaffold with tunable properties might have potential applications for microtia reconstruction.

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聚乙烯醇/胶原/明胶支架的制备与表征。

聚乙烯醇（PVA）是组织工程中常用的支架材料。然而，PVA在实现适合天然软骨的机械性能方面存在局限性。胶原蛋白和明胶是天然聚合物，具有生物相容性，可生物降解的特性，免疫反应低。本研究采用聚乙烯醇/胶原/明胶（PVA/Coll/Gel）复合材料进行微体重建。考察并优化了5、10、15、20和25%的胶原添加量对PVA/Coll/Gel的x射线衍射（XRD）、红外光谱、微观结构、弹性模量和溶胀性能的影响。XRD分析结果表明，含20%和25%胶原的PVA/Coll/Gel支架由半晶向无定形转变。所研制的胶原蛋白含量分别为15%、20%和25%的复合材料具有与人耳软骨相似的机械强度。孔径最大（~ 66.47 μm）的PVA/Coll 5%/Gel支架的溶胀率最高。结果表明，具有可调性能的PVA/Coll/Gel支架在小体重建中具有潜在的应用前景。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Biomaterials Applications 工程技术-材料科学：生物材料

CiteScore

5.10

自引率

3.40%

发文量

144

审稿时长

1.5 months

期刊介绍： The Journal of Biomaterials Applications is a fully peer reviewed international journal that publishes original research and review articles that emphasize the development, manufacture and clinical applications of biomaterials. Peer-reviewed articles by biomedical specialists from around the world cover: New developments in biomaterials, R&D, properties and performance, evaluation and applications Applications in biomedical materials and devices - from sutures and wound dressings to biosensors and cardiovascular devices Current findings in biological compatibility/incompatibility of biomaterials The Journal of Biomaterials Applications publishes original articles that emphasize the development, manufacture and clinical applications of biomaterials. Biomaterials continue to be one of the most rapidly growing areas of research in plastics today and certainly one of the biggest technical challenges, since biomaterial performance is dependent on polymer compatibility with the aggressive biological environment. The Journal cuts across disciplines and focuses on medical research and topics that present the broadest view of practical applications of biomaterials in actual clinical use. The Journal of Biomaterial Applications is devoted to new and emerging biomaterials technologies, particularly focusing on the many applications which are under development at industrial biomedical and polymer research facilities, as well as the ongoing activities in academic, medical and applied clinical uses of devices.