Dynamic injectable photothermal/chemotherapeutic hydrogel for prevention and treatment of local wound infections.

IF 2.5 4区医学 Q3 ENGINEERING, BIOMEDICAL

Journal of Biomaterials Applications Pub Date : 2025-08-30 DOI:10.1177/08853282251375205

Chensong Zhang, Zhenzhen Hui, Jiachi Ma

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引用次数: 0

Abstract

Various dressings have been developed for the prevention and treatment of wound infections, but the complex structures and manufacturing processes designed to achieve powerful functionalities have impeded their clinical application. Herein, a dynamic injectable photothermal/chemotherapeutic hydrogel has been facilely established through mixing gellan gum (GG), indocyanine green (ICG) and amikacin (AMI) aqueous solutions at 80°C and cooling to room temperature. The hydrogel displayed a precise structure with 1.5% of GG containing ICG content of 100 μg/mL and AMI content of 1 mg/mL, and exhibited favorable injectable, self-healing, and adhesive capabilities as well as superior swelling and moisturizing properties through GG's features. Furthermore, the GG also endowed the hydrogel with the capability to efficiently release drugs in response to the microenvironment (pH 5.0, 7.4 and 8.0) of both infected and uninfected wounds. These exceptional physicochemical properties and combined effects of chemotherapy and PTT facilitated the satisfactory in vitro biocompatibility and antibacterial capability as well as wound healing acceleration ability. Therefore, such a dynamic injectable photothermal/chemotherapeutic hydrogel paves the way toward easily clinical transformation for prevention and treatment of local wound infections.

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动态注射光热/化疗水凝胶用于预防和治疗局部伤口感染。

为了预防和治疗伤口感染，已经开发了各种各样的敷料，但是为了实现强大的功能而设计的复杂结构和制造工艺阻碍了它们的临床应用。本文通过将结冷胶（GG）、吲哚菁绿（ICG）和阿米卡星（AMI）水溶液在80℃下混合并冷却至室温，制备了一种动态可注射光热/化疗水凝胶。该水凝胶结构精细，含有1.5%的GG， ICG含量为100 μg/mL， AMI含量为1 mg/mL，并通过GG的特性表现出良好的注射、自愈和粘接能力以及良好的肿胀和保湿性能。此外，GG还赋予水凝胶有效释放药物的能力，以响应感染和未感染伤口的微环境（pH 5.0, 7.4和8.0）。这些特殊的物理化学性质和化疗与PTT的联合作用，使其具有良好的体外生物相容性和抗菌能力，以及促进伤口愈合的能力。因此，这种动态可注射光热/化疗水凝胶为预防和治疗局部伤口感染的临床转化铺平了道路。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Biomaterials Applications 工程技术-材料科学：生物材料

CiteScore

5.10

自引率

3.40%

发文量

144

审稿时长

1.5 months

期刊介绍： The Journal of Biomaterials Applications is a fully peer reviewed international journal that publishes original research and review articles that emphasize the development, manufacture and clinical applications of biomaterials. Peer-reviewed articles by biomedical specialists from around the world cover: New developments in biomaterials, R&D, properties and performance, evaluation and applications Applications in biomedical materials and devices - from sutures and wound dressings to biosensors and cardiovascular devices Current findings in biological compatibility/incompatibility of biomaterials The Journal of Biomaterials Applications publishes original articles that emphasize the development, manufacture and clinical applications of biomaterials. Biomaterials continue to be one of the most rapidly growing areas of research in plastics today and certainly one of the biggest technical challenges, since biomaterial performance is dependent on polymer compatibility with the aggressive biological environment. The Journal cuts across disciplines and focuses on medical research and topics that present the broadest view of practical applications of biomaterials in actual clinical use. The Journal of Biomaterial Applications is devoted to new and emerging biomaterials technologies, particularly focusing on the many applications which are under development at industrial biomedical and polymer research facilities, as well as the ongoing activities in academic, medical and applied clinical uses of devices.