Association of fetal FTO gene variants with maternal postload glucose levels in pregnancy.

IF 3.8 2区医学 Q1 ENDOCRINOLOGY & METABOLISM

International Journal of Obesity Pub Date : 2025-08-28 DOI:10.1038/s41366-025-01896-1

Gábor Firneisz, Ákos Nádasdi, Botond A Nemes, László Németh, Klara Rosta, Jürgen Harreiter, Alexandra Kautzky-Willer, Anikó Somogyi, Zoltán Benyó

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引用次数: 0

Abstract

Objective: The FTO rs9939609 variant is a major common genetic risk factor of adult obesity. We hypothesized that the rs9939609 variant of the fetus alters the plasma glucose (PG) levels during oral glucose tolerance test (OGTT) routinely performed between the 24-28th gestational week.

Methods: We analysed the data of mother-neonate pairs from our prior gestational diabetes mellitus (GDM) case-control study (Hungarian-Austrian set, n = 858) and the HAPO study European ancestry subset (HAPO-EUR, n = 1374) using pre-pregnancy body mass index (BMI) and maternal age as covariates. The rs8050136 (complete LD with rs9939609) was used in the HAPO-EUR data set.

Results: Fetal FTO variants were associated (dominant genetic model) with decreased maternal 60'min PG values (ß_{Hungarian-Austrian} = -1.39 mmol/L, p = 1.97*10^-4; ß_HAPO-EUR = -0.18 mmol/L, p = 4.36*10^-2; ß_combined = -0.33 mmol/L, p = 2.11*10^-4) and with reduced incremental area under glucose curve at OGTT (ß_{Hungarian-Austrian} =-1.70 mmol*h/L, p = 3.83*10^-4; ß_HAPO-EUR = -0.23 mmol*h/L, p = 2.91*10^-2; ß_combined = -0.39 mmol*h/L, p = 1.61*10^-4).

Conclusion: FTO risk variants carried by the fetus may indirectly influence maternal metabolism and could be associated with a flatter OGTT curve driven by the reduced 1 h postload PG levels in pregnancy.

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胎儿FTO基因变异与孕妇负荷后血糖水平的关系。

目的：FTO rs9939609变异是成人肥胖的主要常见遗传危险因素。我们假设胎儿的rs9939609变异在妊娠24-28周的常规口服葡萄糖耐量试验（OGTT）中改变血浆葡萄糖（PG）水平。方法：我们以孕前体重指数（BMI）和母亲年龄为协变量，分析了来自既往妊娠糖尿病（GDM）病例对照研究（匈牙利-奥地利组，n = 858）和HAPO研究欧洲血统亚组（HAPO- eur, n = 1374）的母亲-新生儿对数据。rs8050136（完整LD与rs9939609）用于HAPO-EUR数据集。结果：胎儿FTO变异与母体60'min PG值降低（ß hungarian - austria = -1.39 mmol/L, p = 1.97*10-4； ßHAPO-EUR = -0.18 mmol/L, p = 4.36*10-2； ßcombined = -0.33 mmol/L, p = 2.11*10-4）和OGTT葡萄糖曲线下增量面积减少（ß hungarian - austria =-1.70 mmol*h/L, p = 3.83*10-4； ßHAPO-EUR = -0.23 mmol*h/L, p = 2.91*10-2； ßcombined = -0.39 mmol*h/L, p = 1.61*10-4）相关。结论：胎儿携带的FTO风险变异可能间接影响母体代谢，并可能与妊娠期负荷后1 h PG水平降低导致OGTT曲线变平有关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International Journal of Obesity 医学-内分泌学与代谢

CiteScore

10.00

自引率

2.00%

发文量

221

审稿时长

3 months

期刊介绍： The International Journal of Obesity is a multi-disciplinary forum for research describing basic, clinical and applied studies in biochemistry, physiology, genetics and nutrition, molecular, metabolic, psychological and epidemiological aspects of obesity and related disorders. We publish a range of content types including original research articles, technical reports, reviews, correspondence and brief communications that elaborate on significant advances in the field and cover topical issues.