Exosomes-Based Nanotherapeutic Strategies: An Important Approach for Spinal Cord Injury Repair.

IF 6.5 2区医学 Q1 NANOSCIENCE & NANOTECHNOLOGY

International Journal of Nanomedicine Pub Date : 2025-08-27 eCollection Date: 2025-01-01 DOI:10.2147/IJN.S539673

Cheng Ju, Hui Dong, Renfeng Liu, Xuan Wang, Ruiqing Xu, Huimin Hu, Dingjun Hao

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Abstract

The repair and functional regeneration of spinal cord injury (SCI) remains a major challenge and focal point in regenerative medicine. Following SCI significant inflammation and neuronal damage occur. Conventional drug therapies often fail to precisely target the injured areas and cannot cross the blood-spinal cord barrier, severely limiting therapeutic efficacy. Therefore, precision therapeutics are crucial to improve the prognosis of SCI patients. In recent years, exosomes have gained widespread attention as natural delivery vehicles due to their low immunogenicity, high biocompatibility, and efficient delivery capabilities. Exosomes can effectively cross cell membranes and target specific cells, playing an important role in intercellular signaling. This makes them highly promising for precision therapies in SCI. By engineering exosomes for targeted delivery, new strategies can be developed for drug delivery, gene therapy, and personalized treatment after SCI. We aimed to review the biological functions of exosomes derived from different cell sources and discuss the role in tissue repair following SCI. Additionally, we explore the prospects and potential of exosomes in clinical SCI applications, to provide valuable research insights to improve functional recovery and long-term health management for SCI patients in the future.

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基于外泌体的纳米治疗策略：脊髓损伤修复的重要途径。

脊髓损伤的修复和功能再生一直是再生医学研究的热点和难点。脊髓损伤后出现明显的炎症和神经元损伤。传统的药物治疗往往不能精确地靶向损伤区域，也不能穿过血脊髓屏障，严重限制了治疗效果。因此，精准治疗对于改善脊髓损伤患者的预后至关重要。近年来，外泌体因其低免疫原性、高生物相容性和高效的递送能力而受到广泛关注。外泌体可以有效地跨越细胞膜并靶向特定细胞，在细胞间信号传导中发挥重要作用。这使得它们在脊髓损伤的精确治疗中非常有希望。通过对外泌体进行靶向递送，可以为脊髓损伤后的药物递送、基因治疗和个性化治疗开发新的策略。我们旨在回顾来自不同细胞来源的外泌体的生物学功能，并讨论其在脊髓损伤后组织修复中的作用。此外，我们还探讨了外泌体在SCI临床应用中的前景和潜力，为未来改善SCI患者的功能恢复和长期健康管理提供有价值的研究见解。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International Journal of Nanomedicine NANOSCIENCE & NANOTECHNOLOGY-PHARMACOLOGY & PHARMACY

CiteScore

14.40

自引率

3.80%

发文量

511

审稿时长

1.4 months

期刊介绍： The International Journal of Nanomedicine is a globally recognized journal that focuses on the applications of nanotechnology in the biomedical field. It is a peer-reviewed and open-access publication that covers diverse aspects of this rapidly evolving research area. With its strong emphasis on the clinical potential of nanoparticles in disease diagnostics, prevention, and treatment, the journal aims to showcase cutting-edge research and development in the field. Starting from now, the International Journal of Nanomedicine will not accept meta-analyses for publication.