Prevalence of Human Leukocyte Antigen Alleles Polymorphism in North Indian Population.

IF 0.8 Q4 UROLOGY & NEPHROLOGY

Indian Journal of Nephrology Pub Date : 2025-07-01 Epub Date: 2024-09-18 DOI:10.25259/ijn_516_23

Brijesh Yadav, Narayan Prasad, Ravi Shanker Kushwaha, Manas Patel, Dharmendra Singh Bhadauria, Anupma Kaul

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Abstract

Background: Human leukocyte antigens (HLA) are highly polymorphic glycoproteins required for immune response and recognizing self or non-self. Knowing the HLA diversity in a population may be helpful in the selection of organ allocation for transplantation. We aimed to retrospectively analyze the prevalence of HLA, A, B, C, DRB1, and DQA1 alleles frequency in the north Indian population.

Materials and methods: HLA antigen allele data were retrospectively analyzed from a transplant cohort of 2259 subjects. HLA-A, B, and DRB1 frequency were determined in 2259, HLA-C in 759 and DQA1 in 751 subjects.

Results: The most abundant HLA-A antigen alleles were HLA-A*01(25.41%), HLA-A*02 (24.83%), HLA-A*11 (17.53%), HLA-A*24 (10.27%), HLA-A*03 (9.07%). HLA-B antigen alleles were HLA-B*35 (20.54%), HLA-B*15 (15.36%), HLA-B*40 (13.59%), HLA-B*07 (10.14%), HLA-B*44 (7.79). HLA-C antigen alleles were HLA-C*07 (28.06%), HLA-C*04 (20.42%), HLA-C*03 (15.55%), HLA-C*06 (13.04%), HLA-C*12 (5.27%). HLA-DRB1 alleles were HLA-DRB1*07 (21.60%), HLA-DRB1*04 (19.74%), HLA-DRB1*10 (13.15%), HLA-DRB1*03 (10.80%), HLA-DRB1*11 (8.63%). HLA-DQA1 antigen alleles were HLA-DQA1*03 (35.42%), HLA-DQA1*02 (30.89%), HLA-DQA1*05 (21.84%), HLA-DQA1* 06 (10.12%), HLA-DQA1*04 (1.07%).

Conclusion: The most frequent HLA alleles were HLA-A*01(25.41%), HLA-B*35 (20.54%), HLA-C*07 (28.06%), HLA-DRB1*07(21.60%), HLA-DQA1*03(35.42%) in north Indian population.

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北印度人群白细胞抗原等位基因多态性的流行。

背景：人类白细胞抗原（HLA）是一种高度多态性的糖蛋白，是免疫应答和识别自身或非自身所必需的。了解人群的HLA多样性可能有助于器官移植分配的选择。我们旨在回顾性分析印度北部人群中HLA、A、B、C、DRB1和DQA1等位基因频率的流行情况。材料和方法：回顾性分析2259例移植队列患者的HLA抗原等位基因数据。2259名受试者检测HLA-A、B和DRB1频率，759名受试者检测HLA-C频率，751名受试者检测DQA1频率。结果：HLA-A抗原等位基因丰度最高的是HLA-A*01（25.41%）、HLA-A*02（24.83%）、HLA-A*11（17.53%）、HLA-A*24（10.27%）、HLA-A*03（9.07%）。HLA-B抗原等位基因为HLA-B*35（20.54%）、HLA-B*15（15.36%）、HLA-B*40（13.59%）、HLA-B*07（10.14%）、HLA-B*44（7.79）。HLA-C抗原等位基因为HLA-C*07（28.06%）、HLA-C*04（20.42%）、HLA-C*03（15.55%）、HLA-C*06（13.04%）、HLA-C*12（5.27%）。HLA-DRB1等位基因为HLA-DRB1*07（21.60%）、HLA-DRB1*04（19.74%）、HLA-DRB1*10（13.15%）、HLA-DRB1*03（10.80%）、HLA-DRB1*11（8.63%）。HLA-DQA1抗原等位基因为HLA-DQA1*03（35.42%）、HLA-DQA1*02（30.89%）、HLA-DQA1*05（21.84%）、HLA-DQA1* 06（10.12%）、HLA-DQA1*04（1.07%）。结论：印度北部人群HLA等位基因以HLA- a *01（25.41%）、HLA- b *35（20.54%）、HLA- c *07（28.06%）、HLA- drb1 *07（21.60%）、HLA- dqa1 *03（35.42%）最为常见。

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