Impact of Multidisciplinary Collaboration on Microbiological Specimen Submission and Appropriate Use of Carbapenems: A Pre-Post Cohort Study.

IF 2.9 3区医学 Q2 INFECTIOUS DISEASES

Infection and Drug Resistance Pub Date : 2025-08-25 eCollection Date: 2025-01-01 DOI:10.2147/IDR.S532011

Qi Zou, Yatong Zhang, Xiaoman Ai, Xiaoming Tan, Xia Wang, Ji Luo, Meng Cai

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Abstract

Purpose: This study assessed the impact of multidisciplinary collaborative management on microbiological specimen submission rates and the rational use of carbapenem antibiotics.

Patients and methods: A pre- and post-intervention cohort design was employed. From February to November 2024, a multidisciplinary antimicrobial stewardship intervention was implemented for hospitalized patients receiving carbapenem antibiotics. Patients treated in January 2024 served as the control group, and those in November 2024 formed the intervention group.

Results: Following the intervention, the pathogen testing rate among patients receiving carbapenem treatment increased significantly from 64.76% to 74.27% (p = 0.042), with the most notable improvement in the surgical ward (36.84% to 66.07%, p < 0.001). The blood culture qualification rate increased from 34.29% to 60.47% (p = 0.009), and the blood culture submission rate also increased from 2.86% to 16.02%, (p < 0.001). Additionally, there were improvements in the targeted therapy, rational antibiotics use, and treatment adjustments based on sensitivity results. However, no significant change was observed in the detection rate of hospital-acquired carbapenem-resistant pathogens (0.46% vs 0.35%, p = 0.341).

Conclusion: A multidisciplinary, information-based intervention significantly improved pathogen testing and promoted more rational carbapenem use, highlighting the value of collaborative antimicrobial stewardship.

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多学科合作对微生物标本提交和碳青霉烯类药物适当使用的影响：一项前后队列研究。

目的：探讨多学科协同管理对微生物标本送检率及碳青霉烯类抗生素合理使用的影响。患者和方法：采用干预前和干预后队列设计。从2024年2月至11月，对使用碳青霉烯类抗生素的住院患者实施多学科抗菌药物管理干预。2024年1月治疗的患者为对照组，2024年11月治疗的患者为干预组。结果：干预后，接受碳青霉烯类药物治疗的患者病原菌检出率由64.76%显著提高至74.27% (p = 0.042)，其中外科病房的检出率由36.84%显著提高至66.07% （p < 0.001）。血培养合格率由34.29%提高到60.47% (p = 0.009)，血培养提交率由2.86%提高到16.02% （p < 0.001）。此外，在靶向治疗、合理使用抗生素和根据敏感性结果调整治疗方面也有改善。医院获得性碳青霉烯耐药病原菌检出率无显著变化（0.46% vs 0.35%, p = 0.341）。结论：多学科、信息化的干预措施显著提高了病原菌检测水平，促进了碳青霉烯类药物的合理使用，凸显了协同抗菌药物管理的价值。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Infection and Drug Resistance Medicine-Pharmacology (medical)

CiteScore

5.60

自引率

7.70%

发文量

826

审稿时长

16 weeks

期刊介绍： About Journal Editors Peer Reviewers Articles Article Publishing Charges Aims and Scope Call For Papers ISSN: 1178-6973 Editor-in-Chief: Professor Suresh Antony An international, peer-reviewed, open access journal that focuses on the optimal treatment of infection (bacterial, fungal and viral) and the development and institution of preventative strategies to minimize the development and spread of resistance.