Gamma-Band Binaural Beats Neuromodulation Enhances P300 Classification in an Auditory Brain-Computer Interface Paradigm

Abstract

While established neuromodulation techniques like transcranial magnetic stimulation and transcranial direct current stimulation have shown potential for enhancing brain-computer interface (BCI) performance, their clinical adoption faces challenges including high implementation costs, technical complexity, and safety concerns. This study investigated binaural beats (BB), a non-invasive auditory neuromodulation method characterized by operational simplicity and minimal adverse effects, as a practical alternative for optimizing auditory P300-BCI. Employing a crossover experimental design, thirty healthy participants underwent gamma-band (40 Hz) and alpha-band (10 Hz) BB stimulation in separate sessions. Auditory oddball paradigm experiments were conducted before and after each BB intervention. Electroencephalogram (EEG) data were decoded using both a machine learning classifier and a deep learning model for P300 classification. Additionally, irregular-resampling auto-spectral analysis (IRASA) was applied to extract aperiodic components from EEG during BB stimulation to evaluate changes in brain state. The results demonstrated frequency-dependent modulation effects: gamma-BB significantly improved P300 classification accuracy while alpha-BB impaired performance. Neurophysiological analysis revealed that gamma-BB decreased the aperiodic exponent, indicating enhanced brain arousal level, whereas alpha-BB produced the opposite pattern. Importantly, the aperiodic parameter change showed a significant association with BCI performance improvement. These findings established gamma-BB as an effective, low-cost neuromodulation strategy for augmenting auditory P300-BCI through brain state modulation.