Ratheesh Rajendran, S Lakshmi Krishna, P Mohammed Ashik, Sajin Madanan, Sangeetha Saji, Hana Hameed
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引用次数: 0
Abstract
Background: The antimicrobial activity was assessed on the basis of the zone of inhibition at different concentrations of strontium doped nano hydroxyapatite and comparing the same with that of Ampicillin.
Aims: The aim of the study was to assess the antimicrobial activity of Strontium doped nano hydroxyapatite (Sr-nHAp) when used as remineralizing agent and the property was compared with the similar effects of Ampicillin.
Methods and material: To focus on the antibacterial properties of Sr-nHAp, bacterial culture was performed in a specialized medium and the antibacterial effectiveness was compared with that of the antimicrobial effect of Ampicillin. The pathogenic culture of Streptococcus mutans and Escherichia coli ( E. coli ) were grown in Brain Heart Infusion media for 24 h at 37°C. Two separate culture plates were assigned for S.mutans and E. coli , each were incorporated with different concentrations of Sr-nHAp and Ampicillin (1 mg/mL). The zone of inhibition around the area inoculated with Sr-nHAp in both S.mutans and E. coli culture plates were assessed and compared with that of Ampicillin.
Statistical analysis: Data was analyzed using the statistical package SPSS 26.0 (SPSS Inc., Chicago, IL) and level of significance was set at P < 0.05.
Results and conclusions: The results of the study proved that there is significant difference in zone of inhibition at 10%, 20% and 30% of Sr-nHAp ( P < 0.05). The antimicrobial activity of Sr-nHAp improves as the concentration increases. It was concluded that 30% Sr-nHAp has shown antimicrobial activity similar to Ampicillin against both S. mutans and E-Coli.
期刊介绍：
Indian Journal of Dental Research (IJDR) is the official publication of the Indian Society for Dental Research (ISDR), India section of the International Association for Dental Research (IADR), published quarterly. IJDR publishes scientific papers on well designed and controlled original research involving orodental sciences. Papers may also include reports on unusual and interesting case presentations and invited review papers on significant topics.
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