Effective Dose Estimation with IDAC and OLINDA for 18F-FDG and 68Ga-PSMA PET/CT Procedures.

IF 1.4 4区医学 Q4 ENVIRONMENTAL SCIENCES

Health physics Pub Date : 2025-08-29 DOI:10.1097/HP.0000000000002034

Fatma Hilal Bikirli, Nesrin Altinsoy, Türkay Toklu

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引用次数: 0

Abstract

Abstract: Internal dosimetry is a part of radiation safety for patients and radiation workers in nuclear medicine procedures. This study retrospectively determined the effective dose for oncology patients undergoing PET/CT scans by using widely used computer codes, and the results were compared with each other and literature. The study focused on the radiopharmaceuticals 18F-FDG (n = 220) and 68Ga-PSMA (n = 85), administered to 305 patients for cancer imaging at Yeditepe University Kosuyolu Hospital's nuclear medicine department. PET dose was calculated using OLINDA/EXM, IDAC-Dose 1.0 and IDAC-Dose 2.1 programs while ImPACT software was used to determine the effective dose from the CT scan. All effective doses were derived in accordance with ICRP 60 and ICRP 103 tissue weighting factors. PET effective doses from highest to lowest were calculated with OLINDA/EXM, IDAC-Dose 1.0, IDAC-Dose 2.1 (ICRP 60) and IDAC-Dose 2.1 (ICRP 103) as 9.96, 9.07, 7.01, 6.28 mSv respectively for 18F-FDG. The highest PET effective dose was also calculated with OLINDA/EXM software as 3.65 mSv for 68Ga-PSMA. For the total effective dose in PET/CT scans, CT contributed about 92% for 68Ga-PSMA protocol and 75% for 18F-FDG protocol.Key words: effective dose; internal dosimetry; 18F-FDG; 68Ga-PSMA; OLINDA/EXM; IDAC Dose 2.1; IDAC-Dose 1.0; PET/CT.

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用IDAC和OLINDA估计18F-FDG和68Ga-PSMA PET/CT程序的有效剂量。

摘要：内剂量测定是核医学过程中患者和放射工作人员辐射安全的重要组成部分。本研究采用广泛使用的计算机编码，回顾性确定肿瘤患者PET/CT扫描的有效剂量，并将结果与文献进行对比。该研究的重点是放射性药物18F-FDG （n = 220）和68Ga-PSMA (n = 85)，在Yeditepe大学Kosuyolu医院核医学科对305名患者进行癌症成像。PET剂量采用OLINDA/EXM、IDAC-Dose 1.0和IDAC-Dose 2.1程序计算，CT扫描有效剂量采用ImPACT软件计算。所有有效剂量均根据ICRP 60和ICRP 103组织加权因子得出。采用OLINDA/EXM计算PET有效剂量，IDAC-Dose 1.0、IDAC-Dose 2.1 （ICRP 60）和IDAC-Dose 2.1 （ICRP 103）对18F-FDG的有效剂量从高到低分别为9.96、9.07、7.01、6.28 mSv。用OLINDA/EXM软件计算68Ga-PSMA的最高PET有效剂量为3.65 mSv。对于PET/CT扫描的总有效剂量，CT对68Ga-PSMA方案贡献约92%，对18F-FDG方案贡献约75%。关键词：有效剂量；内部剂量测定法;18 f-fdg;68 ga-psma;城/ EXM;IDAC剂量2.1；IDAC-Dose 1.0;PET / CT。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Health physics 医学-公共卫生、环境卫生与职业卫生

CiteScore

4.20

自引率

0.00%

发文量

324

审稿时长

3-8 weeks

期刊介绍： Health Physics, first published in 1958, provides the latest research to a wide variety of radiation safety professionals including health physicists, nuclear chemists, medical physicists, and radiation safety officers with interests in nuclear and radiation science. The Journal allows professionals in these and other disciplines in science and engineering to stay on the cutting edge of scientific and technological advances in the field of radiation safety. The Journal publishes original papers, technical notes, articles on advances in practical applications, editorials, and correspondence. Journal articles report on the latest findings in theoretical, practical, and applied disciplines of epidemiology and radiation effects, radiation biology and radiation science, radiation ecology, and related fields.