Research landscape of photodynamic therapy for hepatocellular carcinoma: Hotspots and Prospects from 2012 to 2025.

IF 2.5 3区生物学

Hereditas Pub Date : 2025-08-26 DOI:10.1186/s41065-025-00509-1

Fei Yu, Sihan Yin, Jiayu Zhu, Kewei Sun

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引用次数: 0

Abstract

Objective: To explore the current status and future development of photodynamic therapy (PDT) for hepatocellular carcinoma (HCC). However, this field lacks a comprehensive bibliometric analysis. This study aims to investigate the research content and hotspots in PDT for liver cancer from 2012 to 2025, and to predict future research directions, providing references for subsequent studies.

Methods: We chose the Web of Science Core Collection (WoSCC) database and retrieved articles published in the field between 2012 and 2025. Bibliometric and visualization analyses were performed using R (version 4.4.1), VOSviewer (version 1.6.19), and CiteSpace (version 6.4. R1).

Results: A total of 547 papers were included. We found that the number of publications in this field has steadily increased from 2012 to 2025. China leads with the highest number of publications, followed by the USA, Korea, Germany, and Japan. China has the lowest international co-authorship rate, while Germany and Japan show higher international collaboration rates. The International Journal of Nanomedicine is the most popular journal for publication, whereas Biomaterials ranks first in terms of citations. Our analysis of keywords and the most cited references revealed that current research focuses on the mechanism of PDT-induced apoptosis in HCC, the development of photosensitizers (PSs), nanotechnology-enhanced PDT, and synergistic treatment of HCC with PDT and other therapies. Nanotechnology and multimodal synergistic therapeutic strategies are driving the treatment of HCC.

Conclusion: PDT, as a therapy for HCC, is expected to become a research hotspot. This paper analyzes PDT's current research for HCC, offering references for future research in related fields.

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肝细胞癌光动力治疗研究现状：2012 - 2025年热点与展望

目的：探讨光动力疗法（PDT）治疗肝细胞癌（HCC）的现状及未来发展。然而，这一领域缺乏全面的文献计量分析。本研究旨在调查2012 - 2025年肝癌PDT的研究内容和热点，并预测未来的研究方向，为后续研究提供参考。方法：选择Web of Science Core Collection （WoSCC）数据库，检索该领域2012 - 2025年间发表的论文。使用R（版本4.4.1）、VOSviewer（版本1.6.19）和CiteSpace（版本6.4）进行文献计量学和可视化分析。R1)。结果：共纳入论文547篇。我们发现，从2012年到2025年，该领域的出版物数量稳步增长。中国的论文发表数量最多，其次是美国、韩国、德国和日本。中国的国际合作率最低，而德国和日本的国际合作率更高。《国际纳米医学杂志》是最受欢迎的期刊，而《生物材料》在被引用方面排名第一。我们对关键词和被引文献的分析显示，目前的研究主要集中在PDT诱导肝癌细胞凋亡的机制、光敏剂（ps）的开发、纳米技术增强的PDT以及PDT与其他疗法协同治疗肝癌。纳米技术和多模式协同治疗策略正在推动HCC的治疗。结论：PDT作为HCC的一种治疗方法，有望成为研究热点。本文分析了PDT治疗HCC的研究现状，为今后相关领域的研究提供参考。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Hereditas Biochemistry, Genetics and Molecular Biology-Genetics

CiteScore

3.80

自引率

3.70%

发文量

期刊介绍： For almost a century, Hereditas has published original cutting-edge research and reviews. As the Official journal of the Mendelian Society of Lund, the journal welcomes research from across all areas of genetics and genomics. Topics of interest include human and medical genetics, animal and plant genetics, microbial genetics, agriculture and bioinformatics.