Features of sarcopenic obesity in rheumatoid arthritis patients

IF 2.5 4区医学 Q3 GERIATRICS & GERONTOLOGY

Geriatrics & Gerontology International Pub Date : 2025-08-23 DOI:10.1111/ggi.70149

Yuma Saito, Mochihito Suzuki, Toshihisa Kojima, Hiroto Yamamoto, Yuki Saito, Kenya Terabe, Yoshifumi Ohashi, Ryo Sato, Junya Hasegawa, Yusuke Ohno, Kaoru Nagai, Chinami Ohnishi, Hideshi Sugiura, Hitomi Fujita, Mako Nagayoshi, Masayo Kojima, Shuji Asai, Shiro Imagama

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Abstract

Aim

The present study aimed to determine the proportion of rheumatoid arthritis (RA) patients with sarcopenic obesity and to identify associated factors through assessments of physical function and patient-reported outcomes (PROs).

Methods

A prospective cohort study of 321 RA patients aged 40–79 years was conducted. Participants were classified into four groups—Normal, Obesity, Sarcopenia, and Sarcopenic obesity—based on sarcopenia criteria, which included skeletal muscle mass index, grip strength, and physical function, as well as obesity criteria defined by body fat percentage. Baseline characteristics were analyzed, including evaluations of physical function, such as the Timed Up and Go (TUG) test, as well as PROs, such as the Health Assessment Questionnaire – Disability Index (HAQ-DI).

Results

Sarcopenia was found in 19.6% of participants. Proportions of participants by group were as follows: Normal, 28.7%; Obesity, 51.7%; Sarcopenia, 11.2%; and Sarcopenic obesity, 8.4%. The median disease activity score suggested that remission was achieved in all groups. The TUG and HAQ-DI scores were highest in the Sarcopenic obesity group, showing a significant difference compared with all other groups. Other physical function assessments and PROs were also worse in the Sarcopenic obesity group compared with all other groups.

Conclusions

The proportion of sarcopenic obesity in the present study population of well-controlled RA patients was 8.4%. The Sarcopenic obesity group had significantly higher scores in TUG and HAQ-DI compared with all other groups. We observed not only reduced physical function but also a notable decline in quality of life, as evaluated by PROs, in patients with sarcopenic obesity. Geriatr Gerontol Int 2025; 25: 1323–1331.

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查看原文本刊更多论文

类风湿关节炎患者肌肉减少性肥胖的特征。

目的：本研究旨在确定类风湿关节炎（RA）患者肌肉减少性肥胖的比例，并通过评估身体功能和患者报告的预后（PROs）来确定相关因素。方法：对321例40 ~ 79岁RA患者进行前瞻性队列研究。参与者被分为四组——正常、肥胖、肌肉减少症和肌肉减少症肥胖——基于肌肉减少症的标准，包括骨骼肌质量指数、握力和身体功能，以及由体脂率定义的肥胖标准。对基线特征进行分析，包括身体功能评估，如Timed Up and Go （TUG）测试，以及PROs，如健康评估问卷-残疾指数（HAQ-DI）。结果：19.6%的参与者出现了肌肉减少症。各组参与者比例如下：正常，28.7%；肥胖,51.7%;Sarcopenia, 11.2%;肌肉减少型肥胖占8.4%。中位疾病活动度评分表明所有组均达到缓解。TUG和HAQ-DI评分以肌少性肥胖组最高，与其他组比较差异有统计学意义。与所有其他组相比，肌肉减少肥胖组的其他身体功能评估和PROs也更差。结论：在本研究人群中，控制良好的RA患者中肌肉减少型肥胖的比例为8.4%。肌少性肥胖组的TUG和HAQ-DI得分明显高于其他各组。我们观察到，在肌肉减少型肥胖患者中，不仅身体功能下降，而且生活质量也显著下降。Geriatr Gerontol 2025；••: ••-••.

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Geriatrics & Gerontology International 医学-老年医学

CiteScore

5.50

自引率

6.10%

发文量

189

审稿时长

4-8 weeks

期刊介绍： Geriatrics & Gerontology International is the official Journal of the Japan Geriatrics Society, reflecting the growing importance of the subject area in developed economies and their particular significance to a country like Japan with a large aging population. Geriatrics & Gerontology International is now an international publication with contributions from around the world and published four times per year.