Folic Acid Supplementation in Spina Bifida Prophylaxis: Results from the Zurich Fetal Surgery Cohort.

IF 1.6 3区医学 Q3 OBSTETRICS & GYNECOLOGY

Fetal Diagnosis and Therapy Pub Date : 2025-08-22 DOI:10.1159/000547609

Martina Hofmann, Julia Wawrla-Zepf, Ladina Rüegg, Nele Strübing, Martin Meuli, Ueli Moehrlen, Nicole Ochsenbein-Kölble, Ladina Vonzun

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引用次数: 0

Abstract

Introduction: Since preconceptional folic acid (FA) supplementation is known to reduce the risk of fetal spina bifida (fSB), the aim of this study was to systematically analyze the FA supplementation in a cohort of women with fSB repair in affected and subsequent pregnancies.

Methods: A total of 198 women, that underwent open fSB repair between 2010 and 2023, were compared in two groups (group 1 = correct FA and group 2 = incorrect FA preconceptionally) regarding maternal and fetal characteristics. Additionally, compliance to high dose FA supplementation in subsequent pregnancies was analyzed.

Results: Sixty-five women (32.8%) had correct preconceptional FA supplementation (group 1), and 63 women (31.8%) had incorrect FA supplementation (group 2). The two groups did not significantly differ regarding maternal and fetal characteristics. Thirty-nine women had 48 subsequent pregnancies. FA was initiated prior to conception in 35 (72.9%) of these pregnancies, in 9 (18.7%) cases, FA supplementation was incorrect.

Conclusion: This study focuses on better awareness of FA supplementation as correct FA supplementation was low in women with fSB and suboptimal in high-risk situations after fSB pregnancies. However, these results also show that 1/2 of fSB occurs despite correct FA intake; thus, further research is needed to better understand the complex, multifactorial causes of this debilitating condition.

查看原文本刊更多论文

补充叶酸预防脊柱裂：来自苏黎世胎儿手术队列的结果。

导读：由于已知孕前补充叶酸（FA）可以降低胎儿脊柱裂（fSB）的风险，本研究的目的是系统地分析在受影响和随后怀孕的fSB修复妇女队列中补充叶酸的情况。方法：2010-2023年间行开放式fSB修复术的198名妇女，将两组（1组=正确FA， 2组=先入为主错误FA）的母胎特征进行比较。此外，还分析了后续妊娠对高剂量FA补充的依从性。结果：65名妇女（32.8%）在孕前正确补充了FA（第一组），63名妇女（31.8%）补充了不正确的FA（第二组）。两组在母胎特征上无显著差异。39名妇女随后怀孕48次。其中35例（72.9%）孕妇在受孕前就开始补充脂肪酸，9例（18.7%）补充脂肪酸是不正确的。结论：本研究的重点是提高对FA补充的认识，因为fSB妇女的正确FA补充较低，而在fSB妊娠后的高风险情况下，FA补充不是最佳的。然而，这些结果也表明，尽管摄入了正确的FA，仍有1/2的fSB发生，因此需要进一步的研究来更好地了解这种使人衰弱的疾病的复杂的、多因素的原因。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Fetal Diagnosis and Therapy 医学-妇产科学

CiteScore

4.70

自引率

9.10%

发文量

审稿时长

6-12 weeks

期刊介绍： The first journal to focus on the fetus as a patient, ''Fetal Diagnosis and Therapy'' provides a wide range of biomedical specialists with a single source of reports encompassing the common discipline of fetal medicine.