Tricuspid transcatheter edge-to-edge repair versus surgery for tricuspid regurgitation: a systematic review and meta-analysis.

IF 2.1 Q3 CARDIAC & CARDIOVASCULAR SYSTEMS

Expert Review of Cardiovascular Therapy Pub Date : 2025-09-01 Epub Date: 2025-08-22 DOI:10.1080/14779072.2025.2549018

Michail Penteris, Konstantinos Lampropoulos

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引用次数: 0

Abstract

Introduction: To perform a systematic review and meta-analysis to compare the safety, early and late mortality, morbidity and long-term function of the tricuspid valve (TV) following tricuspid transcatheter edge-to-edge repair (T-TEER) compared to surgical tricuspid valve (TV) repair/replacement (TVR) for tricuspid regurgitation (TR).

Methods: This review investigates through two different databases for original studies that evaluated patients with TR who underwent either T-TEER or TVR was until December 2024. The outcomes of interest were safety, morbidity, mortality and long-term function following T-TEER vs TVR.

Results: We identified three retrospective observational studies, including a total of 1612 patients with TR. Short-term (OR, 0.36; 95% CI, 0.13-1.04; p = 0.06) and long-term mortality was similar between T-TEER and TVR. There was a lower risk of acute kidney injury (AKI) (OR, 0.31; 95% CI, 0.23-0.43; p < 0.00001) and permanent pacemaker implantation (PPI) (OR, 0.19; 95% CI, 0.10-0.35; p < 0.00001) with T-TEER, while there was no significant difference in terms of stroke events (OR, 1.17; 95% CI, 0.68-2.01; p = 0.58) and risk of bleeding (OR, 0.81; 95% CI, 0.45-1.44; p = 0.47) compared to TVR.

Conclusions: In conclusion, T-TEER appears to have a comparable safety profile to TVR with a lower risk of AKI and PPI. However, these findings are based on limited observational data and should be interpreted as hypothesis-generating rather than conclusive.

Registration: This systematic review and meta-analysis was prospectively registered on the international prospective register of systematic reviews (PROSPERO; CRD42024622555).

查看原文本刊更多论文

三尖瓣经导管边缘对边缘修复与手术治疗三尖瓣反流：一项系统回顾和荟萃分析。

通过系统回顾和荟萃分析，比较三尖瓣经导管边缘到边缘修复（T-TEER）与手术三尖瓣修复/置换（TVR）治疗三尖瓣反流（TR）的安全性、早期和晚期死亡率、发病率和长期功能。方法：本综述通过两个不同的原始研究数据库进行调查，这些研究评估了截至2024年12月接受T-TEER或TVR治疗的TR患者。关注的结果是T-TEER与TVR的安全性、发病率、死亡率和长期功能。结果：我们纳入了3项回顾性观察性研究，共纳入1612例TR患者。T-TEER和TVR的短期（OR, 0.36; 95% CI, 0.13-1.04; p = 0.06）和长期死亡率相似。与TVR相比，急性肾损伤（AKI）的风险（OR, 0.31; 95% CI, 0.23-0.43; p p p = 0.58）和出血风险（OR, 0.81; 95% CI, 0.45-1.44; p = 0.47）较低。结论：总之，T-TEER似乎具有与TVR相当的安全性，AKI和PPI的风险更低。然而，这些发现是基于有限的观测数据，应该被解释为假设产生，而不是结论性的。注册：该系统评价和荟萃分析已在国际前瞻性系统评价注册（PROSPERO; CRD42024622555）上前瞻性注册。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Expert Review of Cardiovascular Therapy CARDIAC & CARDIOVASCULAR SYSTEMS-

CiteScore

3.70

自引率

0.00%

发文量

期刊介绍： Expert Review of Cardiovascular Therapy (ISSN 1477-9072) provides expert reviews on the clinical applications of new medicines, therapeutic agents and diagnostics in cardiovascular disease. Coverage includes drug therapy, heart disease, vascular disorders, hypertension, cholesterol in cardiovascular disease, heart disease, stroke, heart failure and cardiovascular surgery. The Expert Review format is unique. Each review provides a complete overview of current thinking in a key area of research or clinical practice.