Cohort profile: the West-China hospital alliance longitudinal epidemiology wellness (WHALE) study.

IF 5.9 1区医学 Q1 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH

European Journal of Epidemiology Pub Date : 2025-08-23 DOI:10.1007/s10654-025-01290-1

Yifei Lin, Yong Yang, Zhuyue Li, Liang Du, Rui Shi, Qingke Shi, Xueru Xu, Geng Yin, Fan Zhang, Wenxia Huang, Yan Huang, Ga Liao, Qilin Liu, Weimin Li, Huan Song, Jin Huang

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引用次数: 0

Abstract

The West-China Hospital Alliance Longitudinal Epidemiology Wellness (WHALE) Study establishes a robust, multidimensional database to provide comprehensive insights into health-to-disease transitions, advancing proactive healthcare and enhancing understanding of the interplay among genetic, behavioral, and environmental factors in disease. The WHALE Study includes a database and a cohort. The WHALE Database, established in 2010, integrates health check-up data from 11 hospitals, covering sociodemographic, lifestyle, medical history, and clinical data. The WHALE Health Trajectory Cohort, launched in November 2024, recruits adults with at least three health check-ups, featuring biennial active follow-ups and passive linkage with regional healthcare databases. As of January 2025, the WHALE Database includes over 3.4 million health records from 1,526,686 participants, with a mean age of 40.3 years and a balanced gender distribution. Notably, 23.88% of participants had at least three health check-ups, and 3.31% had more than ten, highlighting a significant proportion with repeated measurements. The study provides key insights into health trajectories by examining the associations of biomarker data and their trajectory patterns with aging, pre-disease conditions, and disease diagnoses. The strengths of the WHALE Study include its large sample size, longitudinal design, diverse representation, comprehensive data, and robust quality control. Limitations include potential selection bias, data variability across centers, and reliance on self-reported data for some variables.

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队列简介：华西医院联盟纵向流行病学健康研究。

华西医院联盟的纵向流行病学健康（WHALE）研究建立了一个强大的多维数据库，为健康到疾病的转变提供全面的见解，促进积极的医疗保健，并加强对疾病中遗传、行为和环境因素相互作用的理解。WHALE研究包括一个数据库和一个队列。2010年建立的鲸鱼数据库整合了11家医院的健康检查数据，涵盖社会人口、生活方式、病史和临床数据。鲸鱼健康轨迹队列于2024年11月启动，招募至少进行过三次健康检查的成年人，两年一次的主动随访和与区域医疗保健数据库的被动联系。截至2025年1月，鲸鱼数据库包括来自1,526,686名参与者的340多万份健康记录，平均年龄为40.3岁，性别分布均衡。值得注意的是，23.88%的参与者至少进行了三次健康检查，3.31%的参与者进行了十次以上的健康检查，突出了重复测量的显着比例。该研究通过检查生物标志物数据及其轨迹模式与衰老、疾病前期状况和疾病诊断的关联，为健康轨迹提供了关键见解。WHALE研究的优势包括样本量大、纵向设计、代表性多样化、数据全面以及强有力的质量控制。局限性包括潜在的选择偏差，跨中心的数据可变性，以及对某些变量的自我报告数据的依赖。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

European Journal of Epidemiology 医学-公共卫生、环境卫生与职业卫生

CiteScore

21.40

自引率

1.50%

发文量

109

审稿时长

6-12 weeks

期刊介绍： The European Journal of Epidemiology, established in 1985, is a peer-reviewed publication that provides a platform for discussions on epidemiology in its broadest sense. It covers various aspects of epidemiologic research and statistical methods. The journal facilitates communication between researchers, educators, and practitioners in epidemiology, including those in clinical and community medicine. Contributions from diverse fields such as public health, preventive medicine, clinical medicine, health economics, and computational biology and data science, in relation to health and disease, are encouraged. While accepting submissions from all over the world, the journal particularly emphasizes European topics relevant to epidemiology. The published articles consist of empirical research findings, developments in methodology, and opinion pieces.