Serum ZO-1 and occludin levels in bipolar disorder patients.

IF 3.7 3区医学 Q1 CLINICAL NEUROLOGY

European Archives of Psychiatry and Clinical Neuroscience Pub Date : 2025-09-01 DOI:10.1007/s00406-025-02097-7

Pınar Aydogan Avşar, Merve Akkuş

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Abstract

Bipolar disorder is a mental illness with a complex and multidimensional etiology. The blood-brain barrier (BBB) is a semi-permeable barrier between the central nervous system (CNS) and peripheral circulation that protects the CNS from external threats. The healthy functioning of the BBB is ensured by tight junctions (TJs) between cells. This research aims to investigate the serum levels of TJ proteins occludin and zonula occludens-1 protein (ZO-1) in bipolar disorder to elucidate etiopathogenesis. This study included 40 BD patients (20 manic episodes, 20 euthymic episodes) and 40 healthy controls. Serum occludin and ZO-1 values were obtained and compared between the two groups. The serum occludin and ZO-1 levels were significantly higher in the bipolar disorder patients. The analysis of covariance (ANCOVA) revealed a significant main effect of groups in the serum occludin and ZO-1 levels and an effect that was independent of age, gender, BMI, and smoking.BBB disruption and neuroinflammation may play a role in bipolar disorder etiopathogenesis. Occludin and ZO-1 may serve as potential biomarkers for BBB leakage in bipolar disorder. Further research may lead to additional pharmacological therapies targeting BBB for drug-resistant bipolar disorder patients.

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双相情感障碍患者血清ZO-1和occludin水平。

双相情感障碍是一种具有复杂和多维病因的精神疾病。血脑屏障（BBB）是中枢神经系统（CNS）和外周循环之间的半透性屏障，保护CNS免受外部威胁。血脑屏障的健康功能是由细胞之间的紧密连接（TJs）保证的。本研究旨在探讨双相情感障碍患者血清TJ蛋白occludin和zonula occluden -1蛋白（ZO-1）的水平，以阐明其发病机制。本研究包括40例双相障碍患者（20例躁狂发作，20例平静发作）和40例健康对照。比较两组患者血清occludin和ZO-1值。双相情感障碍患者血清occludin和ZO-1水平明显升高。协方差分析（ANCOVA）显示血清occludin和ZO-1水平有显著的主效应，且与年龄、性别、BMI和吸烟无关。血脑屏障破坏和神经炎症可能在双相情感障碍的发病机制中起作用。Occludin和ZO-1可能作为双相情感障碍血脑屏障泄漏的潜在生物标志物。进一步的研究可能会导致针对血脑屏障的其他药物治疗耐药双相情感障碍患者。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

European Archives of Psychiatry and Clinical Neuroscience 医学-精神病学

CiteScore

8.80

自引率

4.30%

发文量

154

审稿时长

6-12 weeks

期刊介绍： The original papers published in the European Archives of Psychiatry and Clinical Neuroscience deal with all aspects of psychiatry and related clinical neuroscience. Clinical psychiatry, psychopathology, epidemiology as well as brain imaging, neuropathological, neurophysiological, neurochemical and moleculargenetic studies of psychiatric disorders are among the topics covered. Thus both the clinician and the neuroscientist are provided with a handy source of information on important scientific developments.