Jianyong Tang, Fang Wu, You Wu, Congcong Chen, Peiwen Ning, Wei Wang, Jianfei Shi, Xingyan Guo, Zengguo Wang
{"title":"Analysis of the value of novel inflammatory indicators derived from complete blood count in predicting for pertussis in children.","authors":"Jianyong Tang, Fang Wu, You Wu, Congcong Chen, Peiwen Ning, Wei Wang, Jianfei Shi, Xingyan Guo, Zengguo Wang","doi":"10.1007/s10096-025-05241-2","DOIUrl":null,"url":null,"abstract":"<p><strong>Objective: </strong>Inflammatory indicators derived from complete blood count (CBC) have been shown to exhibit substantial clinical utility across a broad spectrum of infectious and inflammatory conditions, this study aimed to explore the potential value of CBC-derived inflammatory indicators in predicting for pertussis in children.</p><p><strong>Methods: </strong>CBC parameters of all the participants included in this study were collected. The CBC-derived inflammatory indicators evaluated included the neutrophil-to-lymphocyte ratio (NLR), monocyte-to-lymphocyte ratio (MLR), platelet-to-lymphocyte ratio (PLR), [neutrophil + monocyte]-to-lymphocyte ratio (NMLR), systemic immune-inflammation index (SII), and systemic inflammatory response index (SIRI). The predictive value of CBC-derived inflammatory indicators was assessed using the receiver operating characteristic (ROC) curve analysis.</p><p><strong>Results: </strong>A total of 892 pertussis children, 903 children with non-pertussis respiratory tract infection and 1,165 healthy children were included in this study. Compared to healthy children, the PLR in children with pertussis was significantly reduced (p < 0.001), whereas the levels of the other indicators were significantly increased. Simultaneously, the indicators in children with pertussis were significantly lower than those in children with non-pertussis infection. In the comparative analysis of inflammatory indicators across different age subgroups, all indicators in the pertussis group were significantly elevated in children < 2 years old, compared to those in both the non-pertussis group and the healthy group; conversely, in children > 2 years old, these indicators were significantly lower than those observed in the non-pertussis group. The ROC analysis results indicated that, aside from PLR, the CBC-derived inflammatory indicators demonstrated significant value in predicting for pertussis infection in children < 2 years old. Furthermore, the integration of multiple markers could enhance diagnostic performance.</p><p><strong>Conclusion: </strong>CBC-derived inflammatory indicators, particularly NLR and NMLR, may serve as valuable tools for early predicting for pertussis in children under 2 years old in clinical practice.</p>","PeriodicalId":11782,"journal":{"name":"European Journal of Clinical Microbiology & Infectious Diseases","volume":" ","pages":""},"PeriodicalIF":3.0000,"publicationDate":"2025-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"European Journal of Clinical Microbiology & Infectious Diseases","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1007/s10096-025-05241-2","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"INFECTIOUS DISEASES","Score":null,"Total":0}
引用次数: 0
Abstract
Objective: Inflammatory indicators derived from complete blood count (CBC) have been shown to exhibit substantial clinical utility across a broad spectrum of infectious and inflammatory conditions, this study aimed to explore the potential value of CBC-derived inflammatory indicators in predicting for pertussis in children.
Methods: CBC parameters of all the participants included in this study were collected. The CBC-derived inflammatory indicators evaluated included the neutrophil-to-lymphocyte ratio (NLR), monocyte-to-lymphocyte ratio (MLR), platelet-to-lymphocyte ratio (PLR), [neutrophil + monocyte]-to-lymphocyte ratio (NMLR), systemic immune-inflammation index (SII), and systemic inflammatory response index (SIRI). The predictive value of CBC-derived inflammatory indicators was assessed using the receiver operating characteristic (ROC) curve analysis.
Results: A total of 892 pertussis children, 903 children with non-pertussis respiratory tract infection and 1,165 healthy children were included in this study. Compared to healthy children, the PLR in children with pertussis was significantly reduced (p < 0.001), whereas the levels of the other indicators were significantly increased. Simultaneously, the indicators in children with pertussis were significantly lower than those in children with non-pertussis infection. In the comparative analysis of inflammatory indicators across different age subgroups, all indicators in the pertussis group were significantly elevated in children < 2 years old, compared to those in both the non-pertussis group and the healthy group; conversely, in children > 2 years old, these indicators were significantly lower than those observed in the non-pertussis group. The ROC analysis results indicated that, aside from PLR, the CBC-derived inflammatory indicators demonstrated significant value in predicting for pertussis infection in children < 2 years old. Furthermore, the integration of multiple markers could enhance diagnostic performance.
Conclusion: CBC-derived inflammatory indicators, particularly NLR and NMLR, may serve as valuable tools for early predicting for pertussis in children under 2 years old in clinical practice.
期刊介绍：
EJCMID is an interdisciplinary journal devoted to the publication of communications on infectious diseases of bacterial, viral and parasitic origin.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
