Prevalence and genotype distribution of human papillomavirus infection in multi-anatomic sites in men who have sex with men.

IF 2.2 4区 医学 Q3 INFECTIOUS DISEASES
Rui Zhang, Denise Pui-Chung Chan, Ngai Sze Wong, Sze Long Chung, Chi Keung Kwan, Tsz Ho Kwan, Shui Shan Lee
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Abstract

This study aims to estimate the prevalence of human papillomavirus (HPV) infection and describe its genotype distribution in MSM in Hong Kong. In this longitudinal study on Chinese MSM, multi-anatomic site self-sampling and testing for HPV, Chlamydia trachomatis (CT) and Neisseria gonorrhoeae (NG) were performed following survey completion at baseline and one-year follow-up. Overall, 41% (288/701) of MSM completed self-sampled HPV testing. HPV positivity was 29% (78/270) and 33% (42/127) at any anatomic site at baseline and follow-up timepoints, respectively. By anatomic site, HPV positivity was 26%-30%, 2%-4% and 0%-1% from rectal, penile, and pharyngeal specimens, respectively. The incidence of HPV infection was 21.2/100 and 18.9/100 person-years at any anatomic site and rectal site, respectively. Among 109 successfully genotyped samples, the most prevalent were HPV 6 (17%) and HPV 11 (16%), of which 60% of the genotyped samples were vaccine-preventable. Group sex engagement and less frequent condom use were positively associated with HPV infection (P<0.05). The HPV prevalence and incidence in MSM in this study is lower than in Western countries, and low-risk HPV genotypes are more prevalent. The high proportion of vaccine-preventable HPV subtypes underscores the importance of HPV vaccination in preventing infections in MSM.

男男性行为者多解剖部位人乳头瘤病毒感染的流行及基因型分布
本研究旨在估计香港男男性接触者中人类乳头瘤病毒(HPV)感染的流行情况,并描述其基因型分布。在这项针对中国男男性接触者的纵向研究中,在基线调查和1年随访完成后,进行了多解剖部位自采样和HPV、沙眼衣原体(CT)和淋病奈瑟菌(NG)的检测。总体而言,41%(288/701)的男男性行为者完成了自我抽样HPV检测。在基线和随访时间点,任何解剖部位的HPV阳性分别为29%(78/270)和33%(42/127)。从解剖部位来看,直肠、阴茎和咽标本的HPV阳性率分别为26%-30%、2%-4%和0%-1%。在任何解剖部位和直肠部位,HPV感染的发生率分别为21.2/100和18.9/100人年。在109个成功的基因分型样本中,最流行的是HPV 6(17%)和HPV 11(16%),其中60%的基因分型样本是疫苗可预防的。群体性行为和较少使用避孕套与HPV感染呈正相关(P
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来源期刊
Epidemiology and Infection
Epidemiology and Infection 医学-传染病学
CiteScore
4.10
自引率
2.40%
发文量
366
审稿时长
3-6 weeks
期刊介绍: Epidemiology & Infection publishes original reports and reviews on all aspects of infection in humans and animals. Particular emphasis is given to the epidemiology, prevention and control of infectious diseases. The scope covers the zoonoses, outbreaks, food hygiene, vaccine studies, statistics and the clinical, social and public-health aspects of infectious disease, as well as some tropical infections. It has become the key international periodical in which to find the latest reports on recently discovered infections and new technology. For those concerned with policy and planning for the control of infections, the papers on mathematical modelling of epidemics caused by historical, current and emergent infections are of particular value.
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