Comparison of the diagnostic performance of narrow-band imaging endocytoscopy and staining-based endocytoscopy for colorectal lesions.

IF 3.8 3区医学 Q1 GASTROENTEROLOGY & HEPATOLOGY

Digestive and Liver Disease Pub Date : 2025-08-26 DOI:10.1016/j.dld.2025.08.012

Mingqing Liu, Ying Li, Jiawei Fan, He Zhu, Fengming Ni, Tantan Ma, Erli Cui, Nan Zhang, Hong Xu

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Abstract

Background and aims: Endocytoscopy (EC) enables real-time histopathological evaluation through two modes: narrow-band imaging endocytoscopy (ECNBI) and staining-based endocytoscopy (EC-SB). However, the comparative diagnostic accuracy between ECNBI and EC-SB, and their performance of endoscopists with varying levels of experience remains unclear.

Methods: This retrospective study analyzed 565 colorectal lesions from 433 patients. Both expert and non-expert endoscopists evaluated colorectal lesions based on ECNBI and EC-SB images. Sensitivity, specificity, accuracy, positive predictive value (PPV), negative predictive value (NPV), and inter- and intra-observer agreement were compared with histopathological diagnoses.

Results: The sensitivity, specificity, and accuracy for diagnosing hyperplastic polyps by experts using EC-SB are 93.0 %, 98.0 %, and 97.0 %, which were significantly higher than the results of ECNBI (86.8 %, 96.1 %, and 94.2 %, respectively; P < 0.05 for all). Similarly, for diagnosing adenomas to intramucosal cancers, EC-SB by experts achieved significantly higher sensitivity, specificity and accuracy (93.0 %, 94.8 % and 93.6 %) compared to ECNBI (90.2 %, 90.1 % and 90.2 %, respectively; P < 0.05 for all). In addition, for diagnosing invasive cancers, EC-SB by experts showed significantly higher specificity (98.7 % vs. 96.1 %, P < 0.05).

Conclusions: EC-SB demonstrated higher diagnostic accuracy for colorectal lesions among experts, supporting its utility for precise treatment decisions.

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窄带成像细胞镜与染色细胞镜对结直肠病变诊断价值的比较。

背景和目的：内吞镜检查（EC）通过窄带成像内吞镜检查（ECNBI）和基于染色的内吞镜检查（EC- sb）两种模式实现实时组织病理学评估。然而，ECNBI和EC-SB之间的比较诊断准确性，以及不同经验水平的内窥镜医师的表现仍不清楚。方法：回顾性分析433例565例结直肠病变。专家和非专业内窥镜医师均根据ECNBI和EC-SB图像评估结直肠病变。敏感性、特异性、准确性、阳性预测值（PPV）、阴性预测值（NPV）以及观察者之间和观察者内部的一致性与组织病理学诊断进行比较。结果：专家应用EC-SB诊断增殖性息肉的敏感性、特异性和准确性分别为93.0%、98.0%和97.0%，显著高于ECNBI（分别为86.8%、96.1%和94.2%，P均< 0.05）。同样，专家EC-SB诊断腺瘤到粘膜内癌的敏感性、特异性和准确性（93.0%、94.8%和93.6%）均显著高于ECNBI（分别为90.2%、90.1%和90.2%，P均< 0.05）。专家对EC-SB诊断浸润性肿瘤的特异性为98.7%比96.1%,P < 0.05。结论：专家认为EC-SB对结直肠病变具有较高的诊断准确性，支持其用于精确治疗决策的效用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Digestive and Liver Disease 医学-胃肠肝病学

CiteScore

6.10

自引率

2.20%

发文量

632

审稿时长

19 days

期刊介绍： Digestive and Liver Disease is an international journal of Gastroenterology and Hepatology. It is the official journal of Italian Association for the Study of the Liver (AISF); Italian Association for the Study of the Pancreas (AISP); Italian Association for Digestive Endoscopy (SIED); Italian Association for Hospital Gastroenterologists and Digestive Endoscopists (AIGO); Italian Society of Gastroenterology (SIGE); Italian Society of Pediatric Gastroenterology and Hepatology (SIGENP) and Italian Group for the Study of Inflammatory Bowel Disease (IG-IBD). Digestive and Liver Disease publishes papers on basic and clinical research in the field of gastroenterology and hepatology. Contributions consist of: Original Papers Correspondence to the Editor Editorials, Reviews and Special Articles Progress Reports Image of the Month Congress Proceedings Symposia and Mini-symposia.