{"title":"Spironolactone for Acne: Practical Strategies for Optimal Clinical Outcomes.","authors":"Sherry Ershadi, John S Barbieri","doi":"10.12788/cutis.1239","DOIUrl":null,"url":null,"abstract":"<p><p>Spironolactone is an effective systemic treatment for acne in women and likely is an underutilized alternative to oral antibiotics. It is used off label for all types of acne and has shown effectiveness for both facial and truncal acne. We recommend a starting dose of 100 mg/d, as most patients can tolerate it and it has superior effectiveness to lower doses. The most common adverse effects of spironolactone are lightheadedness; headache; and menstrual irregularities, which tend to be dose dependent and can be prevented or treated using combined oral contraceptives. Potassium monitoring is of low usefulness in young healthy women, and studies have not identified an association between spironolactone use and increased risk for cancer. This article provides an overview of spironolactone for the treatment of acne, including recent clinical trials and practical strategies for patient selection, dosing, adverse effect management, and monitoring.</p>","PeriodicalId":11195,"journal":{"name":"Cutis","volume":"116 1","pages":"26-31"},"PeriodicalIF":2.7000,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Cutis","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.12788/cutis.1239","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"DERMATOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Spironolactone is an effective systemic treatment for acne in women and likely is an underutilized alternative to oral antibiotics. It is used off label for all types of acne and has shown effectiveness for both facial and truncal acne. We recommend a starting dose of 100 mg/d, as most patients can tolerate it and it has superior effectiveness to lower doses. The most common adverse effects of spironolactone are lightheadedness; headache; and menstrual irregularities, which tend to be dose dependent and can be prevented or treated using combined oral contraceptives. Potassium monitoring is of low usefulness in young healthy women, and studies have not identified an association between spironolactone use and increased risk for cancer. This article provides an overview of spironolactone for the treatment of acne, including recent clinical trials and practical strategies for patient selection, dosing, adverse effect management, and monitoring.
期刊介绍：
Published since 1965, Cutis is a peer-reviewed clinical journal for the dermatologist, allergist, and general practitioner. The journal is published monthly and focuses on concise clinical articles that present the practical side of dermatology. Referenced in Index Medicus/MEDLINE, it is respected and enjoyed by both specialists and derm-active generalists, enabling its readers to get what they need quickly and efficiently. Furthermore, Cutis is read by more physicians actively involved in the day-to-day treatment of dermatologic conditions than any other dermatology publication. Covering a broad range of pertinent and timely topics, Cutis is written and edited by industry leaders. For information on article submissions, please see our Information for Authors.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
