{"title":"The Skin Microbiome in Rosacea: Mechanisms, Gut-Skin Interactions, and Therapeutic Implications.","authors":"Aniket Asees, Alana Sadur, Sonal Choudhary","doi":"10.12788/cutis.1240","DOIUrl":null,"url":null,"abstract":"<p><p>Rosacea is a chronic inflammatory skin condition of the central face driven by immune dysregulation, genetic predisposition, epidermal barrier dysfunction, and microbial dysbiosis. Recent evidence implicates both the gut and skin microbiomes-through direct immune interactions and the gut-skin axis-in driving cutaneous inflammation and disease severity, with an increase in proinflammatory species such as Demodex folliculorum, Staphylococcus epidermidis, and Bacillus oleronius alongside a decline in protective species such as Cutibacterium acnes. Therapeutic strategies now aim to restore microbial balance using narrow-spectrum antibiotics, anthelmintics, topical and oral probiotics, and microbiome-friendly skin care to reduce inflammation, reinforce skin barrier function, and improve clinical outcomes. Future research to refine precision treatments that target specific microbial and immune pathways would be beneficial to modulate dysbiosis and improve outcomes in rosacea.</p>","PeriodicalId":11195,"journal":{"name":"Cutis","volume":"116 1","pages":"20-23"},"PeriodicalIF":2.7000,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Cutis","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.12788/cutis.1240","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"DERMATOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Rosacea is a chronic inflammatory skin condition of the central face driven by immune dysregulation, genetic predisposition, epidermal barrier dysfunction, and microbial dysbiosis. Recent evidence implicates both the gut and skin microbiomes-through direct immune interactions and the gut-skin axis-in driving cutaneous inflammation and disease severity, with an increase in proinflammatory species such as Demodex folliculorum, Staphylococcus epidermidis, and Bacillus oleronius alongside a decline in protective species such as Cutibacterium acnes. Therapeutic strategies now aim to restore microbial balance using narrow-spectrum antibiotics, anthelmintics, topical and oral probiotics, and microbiome-friendly skin care to reduce inflammation, reinforce skin barrier function, and improve clinical outcomes. Future research to refine precision treatments that target specific microbial and immune pathways would be beneficial to modulate dysbiosis and improve outcomes in rosacea.
期刊介绍：
Published since 1965, Cutis is a peer-reviewed clinical journal for the dermatologist, allergist, and general practitioner. The journal is published monthly and focuses on concise clinical articles that present the practical side of dermatology. Referenced in Index Medicus/MEDLINE, it is respected and enjoyed by both specialists and derm-active generalists, enabling its readers to get what they need quickly and efficiently. Furthermore, Cutis is read by more physicians actively involved in the day-to-day treatment of dermatologic conditions than any other dermatology publication. Covering a broad range of pertinent and timely topics, Cutis is written and edited by industry leaders. For information on article submissions, please see our Information for Authors.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
