Druggable Targets in Zika Virus: A Systematic Review of Therapeutic Opportunities in Brazil.

IF 3.3 4区 医学 Q3 CHEMISTRY, MEDICINAL
Washington Kleber Rodrigues Lima, Claudia Zeneida Gomes Parente Alves Lima, Víctor Kleber Gomes Parente Alves Lima, Willian Reis Rosário, Lidio Gonçalves Lima-Neto, Maria Tereza Dos Santos Correia, Glaucio Monteiro Ferreira, Luís Cláudio Nascimento da Silva
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引用次数: 0

Abstract

Introduction: Zika virus (ZIKV), a flavivirus primarily transmitted by Aedes aegypti, became a major global health concern during the 2015-2016 outbreak, particularly in Brazil. Its association with congenital malformations and neurological disorders underscores the urgent need for effective therapeutic interventions. This review explores molecular targets for ZIKV treatment within the Brazilian context.

Method: A systematic search was conducted using PubMed, ScienceDirect, and Scopus for studies published between 2004 and 2024. Inclusion criteria focused on studies identifying druggable molecular targets related to viral replication, immune evasion, or host-virus interactions. Key search terms included "Zika virus," "molecular targets," "Brazil," "antiviral," and "drug discovery."

Results: The review identified several critical viral proteins, NS1, NS3, NS5, and the envelope protein, as potential drug targets. Host cellular factors essential for viral survival were also highlighted. Technologies such as high-throughput screening, molecular docking, and structural genomics contributed significantly to the identification and validation of these targets.

Discussion: Although promising targets have been identified, therapeutic development is hindered by the genetic variability of ZIKV and its antigenic similarity to other flaviviruses, notably the dengue virus. These challenges complicate the specificity and efficacy of drugs. Nevertheless, Brazil has made strides in research infrastructure and collaborations to tackle these obstacles.

Conclusion: This review synthesizes current knowledge on ZIKV molecular targets and ongoing drug discovery efforts. The findings support the strategic development of antivirals and emphasize the necessity for sustained investment in research to mitigate future ZIKV outbreaks in Brazil and globally.

寨卡病毒的可药物靶点:巴西治疗机会的系统回顾。
寨卡病毒(ZIKV)是一种主要由埃及伊蚊传播的黄病毒,在2015-2016年疫情期间,特别是在巴西,成为一个主要的全球卫生问题。它与先天性畸形和神经系统疾病的关联强调了迫切需要有效的治疗干预措施。这篇综述探讨了巴西寨卡病毒治疗的分子靶点。方法:使用PubMed、ScienceDirect和Scopus系统检索2004 - 2024年间发表的研究。纳入标准侧重于确定与病毒复制、免疫逃避或宿主-病毒相互作用相关的可药物分子靶点的研究。关键搜索词包括“寨卡病毒”、“分子靶点”、“巴西”、“抗病毒药物”和“药物发现”。结果:本综述确定了几个关键的病毒蛋白,NS1、NS3、NS5和包膜蛋白,作为潜在的药物靶点。对病毒存活至关重要的宿主细胞因子也被强调。高通量筛选、分子对接和结构基因组学等技术为这些靶点的鉴定和验证做出了重要贡献。讨论:虽然已经确定了有希望的靶点,但寨卡病毒的遗传变异性及其与其他黄病毒(特别是登革热病毒)的抗原相似性阻碍了治疗的发展。这些挑战使药物的特异性和疗效复杂化。尽管如此,巴西在解决这些障碍的研究基础设施和合作方面取得了长足的进步。结论:本文综述了目前关于寨卡病毒分子靶点的知识和正在进行的药物发现工作。这些发现支持了抗病毒药物的战略性开发,并强调了持续投资研究以减轻巴西和全球未来寨卡病毒疫情的必要性。
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来源期刊
CiteScore
6.40
自引率
2.90%
发文量
186
审稿时长
3-8 weeks
期刊介绍: Current Topics in Medicinal Chemistry is a forum for the review of areas of keen and topical interest to medicinal chemists and others in the allied disciplines. Each issue is solely devoted to a specific topic, containing six to nine reviews, which provide the reader a comprehensive survey of that area. A Guest Editor who is an expert in the topic under review, will assemble each issue. The scope of Current Topics in Medicinal Chemistry will cover all areas of medicinal chemistry, including current developments in rational drug design, synthetic chemistry, bioorganic chemistry, high-throughput screening, combinatorial chemistry, compound diversity measurements, drug absorption, drug distribution, metabolism, new and emerging drug targets, natural products, pharmacogenomics, and structure-activity relationships. Medicinal chemistry is a rapidly maturing discipline. The study of how structure and function are related is absolutely essential to understanding the molecular basis of life. Current Topics in Medicinal Chemistry aims to contribute to the growth of scientific knowledge and insight, and facilitate the discovery and development of new therapeutic agents to treat debilitating human disorders. The journal is essential for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important advances.
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