Biological Aging and Chemotoxicity in Patients with Colorectal Cancer: A Secondary Data Analysis Using EHR Data.

IF 3.4 4区医学 Q2 ONCOLOGY

Current oncology Pub Date : 2025-08-05 DOI:10.3390/curroncol32080438

Claire J Han, Ashley E Rosko, Jesse J Plascak, Alai Tan, Anne M Noonan, Christin E Burd

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引用次数: 0

Abstract

Background: Biological aging influences cancer outcomes, but its changes during chemotherapy and impact on chemotoxicity in colorectal cancer (CRC) remain underinvestigated. We examined (1) trajectories of biological aging (using Levine Phenotypic Age) during six months of chemotherapy, (2) sociodemographic and clinical risk factors for biological aging, and (3) links between biological aging and chemotoxicity. Methods: Using data from electronic health records (2013-2019) from 1129 adult CRC patients, we computed biological aging (raw Levine Phenotypic Age and its age acceleration [Levine Phenotypic Age-chronological age]) from routine blood tests (e.g., complete blood counts, hepatorenal/inflammatory markers). Chemotoxicity was identified primarily via International Classification of Diseases (ICD-9 and -10) codes. Results: Chemotherapy accelerated biological aging over time. Biological aging at baseline and changes over time predicted chemotoxicity. However, changes in biological aging over time showed stronger associations than baseline biological aging. Advanced cancer stages, higher comorbidity burden, and socioeconomic disadvantage (especially area-level deprivation) were associated with accelerated biological aging at baseline and over time. Biological aging occurred across both young and older adults. Conclusions: Levine Phenotypic Age, computed from routine blood tests in EHRs, offers a feasible clinical tool for aging-related chemotoxicity risk stratification. Validation in diverse cohorts and the development of predictive models are needed.

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结直肠癌患者的生物老化和化学毒性：使用电子病历数据的二次数据分析。

背景：生物老化影响癌症预后，但其在化疗期间的变化及其对结直肠癌（CRC）化学毒性的影响仍未得到充分研究。我们研究了(1)六个月化疗期间生物衰老的轨迹（使用Levine表型年龄），(2)生物衰老的社会人口统计学和临床危险因素，以及(3)生物衰老与化学毒性之间的联系。方法：利用1129例成年结直肠癌患者的电子健康记录（2013-2019年）数据，通过常规血液检查（如全血细胞计数、肝肾/炎症标志物）计算生物衰老（原始Levine表型年龄及其年龄加速[Levine表型年龄-实际年龄]）。化学毒性主要通过国际疾病分类（ICD-9和-10）代码确定。结果：随着时间的推移，化疗加速了生物老化。基线的生物老化和随时间的变化预测了化学毒性。然而，随着时间的推移，生物衰老的变化显示出比基线生物衰老更强的相关性。晚期癌症、较高的合并症负担和社会经济劣势（特别是地区贫困）与基线和随时间推移的生物衰老加速有关。生理衰老在年轻人和老年人中都有发生。结论：通过电子病历中的常规血液检查计算得出的Levine表型年龄为衰老相关化学毒性风险分层提供了一种可行的临床工具。需要在不同的队列中进行验证并开发预测模型。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current oncology ONCOLOGY-

CiteScore

3.30

自引率

7.70%

发文量

664

审稿时长

1 months

期刊介绍： Current Oncology is a peer-reviewed, Canadian-based and internationally respected journal. Current Oncology represents a multidisciplinary medium encompassing health care workers in the field of cancer therapy in Canada to report upon and to review progress in the management of this disease. We encourage submissions from all fields of cancer medicine, including radiation oncology, surgical oncology, medical oncology, pediatric oncology, pathology, and cancer rehabilitation and survivorship. Articles published in the journal typically contain information that is relevant directly to clinical oncology practice, and have clear potential for application to the current or future practice of cancer medicine.