{"title":"Guidelines for diagnosing and differentiating infection with antifungal-resistant <i>Trichophyton indotineae</i> from other dermatophytoses.","authors":"Ali Abdul Hussein S Al-Janabi","doi":"10.1080/10408363.2025.2551649","DOIUrl":null,"url":null,"abstract":"<p><p>This review attempts to find a crucial set of criteria that can be applied to diagnose infections caused by <i>Trichophyton indotineae</i>, based on laboratory and clinical characteristics derived from other studies. <i>T. indotineae</i> has emerged as a new species from the anthropophilic <i>Trichophyton mentagrophytes</i> and <i>Trichophyton interdigitale</i>. The close relationship between <i>T. indotineae</i> and these two species makes it difficult to distinguish them based on morphological and physiological features. Resistance to terbinafine was first observed in <i>T. indotineae</i>, and later to other antifungals, which increased the treatment failure rate in several dermatophytoses. In conclusion; identifying criteria specific to infections with <i>T. indotineae</i> can provide a framework for physicians to readily diagnose such infections and distinguish them from other dermatophytoses. Categorization guidelines for all diagnostic characteristics of <i>T. indotineae</i> and its infection can make a forward step in prescribing effective therapies.</p>","PeriodicalId":10760,"journal":{"name":"Critical reviews in clinical laboratory sciences","volume":" ","pages":"1-12"},"PeriodicalIF":5.5000,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Critical reviews in clinical laboratory sciences","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1080/10408363.2025.2551649","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"MEDICAL LABORATORY TECHNOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
This review attempts to find a crucial set of criteria that can be applied to diagnose infections caused by Trichophyton indotineae, based on laboratory and clinical characteristics derived from other studies. T. indotineae has emerged as a new species from the anthropophilic Trichophyton mentagrophytes and Trichophyton interdigitale. The close relationship between T. indotineae and these two species makes it difficult to distinguish them based on morphological and physiological features. Resistance to terbinafine was first observed in T. indotineae, and later to other antifungals, which increased the treatment failure rate in several dermatophytoses. In conclusion; identifying criteria specific to infections with T. indotineae can provide a framework for physicians to readily diagnose such infections and distinguish them from other dermatophytoses. Categorization guidelines for all diagnostic characteristics of T. indotineae and its infection can make a forward step in prescribing effective therapies.
期刊介绍：
Critical Reviews in Clinical Laboratory Sciences publishes comprehensive and high quality review articles in all areas of clinical laboratory science, including clinical biochemistry, hematology, microbiology, pathology, transfusion medicine, genetics, immunology and molecular diagnostics. The reviews critically evaluate the status of current issues in the selected areas, with a focus on clinical laboratory diagnostics and latest advances. The adjective “critical” implies a balanced synthesis of results and conclusions that are frequently contradictory and controversial.
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