Global Incidence and Prevalence of Keratoconus: A Systematic Review and Meta-Analysis.

IF 2.1 3区医学 Q2 OPHTHALMOLOGY

Cornea Pub Date : 2025-08-20 DOI:10.1097/ICO.0000000000003973

Aswen Sriranganathan, Clara C Chan, Jobanpreet Dhillon, Tina Felfeli

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引用次数: 0

Abstract

Purpose: To estimate global incidence and prevalence trends of keratoconus (KC).

Methods: A systematic review and meta-analysis was conducted using MedLine, Embase, and Scopus databases up to January 2024, including all age groups, sexes, and geographic regions. Pooled incidence and prevalence were estimated using random-effects models, with heterogeneity assessed by χ2 and I2 statistics.

Results: This study included 55 studies (53 in meta-analysis). Pooled KC prevalence was 289.1 per 100,000 persons [95% confidence interval (CI) 124.2-671.1] or 0.24% of the population. The pooled incidence was 4.0 per 100,000 person-years (95% CI 2.5-6.3). Males had higher odds of KC compared with females (odds ratio 1.10; 95% CI 1.07-1.13). The 20 to 29 age group had the highest prevalence (525.5 per 100,000 persons; 95% CI 92.6-2822.6) and incidence (20.8 per 100,000 persons-years; 95% CI 12.7-24.1). Prevalence was highest in Africa (2414.2 per 100,000 persons; 95% CI 110.1-1421.5). Prevalence estimates varied significantly across Asian subregions, with lowest prevalence observed in East Asia (12.7 per 100,000 persons; 95% CI 2.81-57.0) and substantially higher rates in West (682.0 per 100,000 persons; 95% CI 141.8-3213.1) and South Asia (1374.5 per 100,000 persons; 95% CI 537.2-3471.5). Prevalence and incidence increased over time, with highest prevalence post-2020 (1155.2 per 100,000 persons; 95% CI 32.4-29682.7) and highest incidence in 2015 to 2019 (15.23 per 100,000 person-years; 95% CI, 8.5-27.3).

Conclusions: Over 23.7 million individuals globally are affected by KC, highlighting an increasing global burden of KC and emphasizing the need for further research into temporal and regional patterns to inform public health strategies and optimize patient care.

查看原文本刊更多论文

圆锥角膜的全球发病率和患病率：系统回顾和荟萃分析。

目的：估计全球圆锥角膜（KC）的发病率和流行趋势。方法：采用截至2024年1月的MedLine、Embase和Scopus数据库进行系统评价和荟萃分析，包括所有年龄组、性别和地理区域。合并发病率和患病率采用随机效应模型估计，异质性采用χ2和I2统计。结果：本研究纳入55项研究（53项荟萃分析）。合并KC患病率为每10万人289.1例[95%可信区间（CI） 124.2-671.1]，占人口的0.24%。合并发病率为每10万人年4.0例（95% CI 2.5-6.3）。男性患KC的几率高于女性（比值比1.10;95% CI 1.07-1.13）。20 - 29岁年龄组患病率最高（525.5 / 10万人；95% CI 92.6-2822.6），发病率最高（20.8 / 10万人-年；95% CI 12.7-24.1）。患病率最高的是非洲（每10万人中有2414.2人；95%可信区间110.1-1421.5）。亚洲各次区域的患病率估计差异很大，东亚的患病率最低（每10万人中有12.7人；95% CI 2.81-57.0），而西方的患病率要高得多（每10万人中有682.0人；95% CI 141.8-3213.1）和南亚（每10万人中有1374.5人；95% CI 537.2-3471.5）。患病率和发病率随着时间的推移而增加，2020年后的患病率最高（1155.2 / 10万人；95% CI 32.4-29682.7）， 2015 - 2019年的发病率最高（15.23 / 10万人年；95% CI, 8.5-27.3）。结论：全球有超过2370万人受到KC的影响，这凸显了KC日益增加的全球负担，并强调需要进一步研究时间和区域模式，为公共卫生战略提供信息并优化患者护理。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cornea 医学-眼科学

CiteScore

5.20

自引率

10.70%

发文量

354

审稿时长

3-6 weeks

期刊介绍： For corneal specialists and for all general ophthalmologists with an interest in this exciting subspecialty, Cornea brings together the latest clinical and basic research on the cornea and the anterior segment of the eye. Each volume is peer-reviewed by Cornea''s board of world-renowned experts and fully indexed in archival format. Your subscription brings you the latest developments in your field and a growing library of valuable professional references. Sponsored by The Cornea Society which was founded as the Castroviejo Cornea Society in 1975.