The short-term efficacy of low-frequency rTMS versus continuous theta burst stimulation as early augmentation, targeting right DLPFC in the management of obsessive-compulsive disorder: a randomized clinical study.

IF 4.1 3区医学 Q2 CLINICAL NEUROLOGY

CNS Spectrums Pub Date : 2025-08-26 DOI:10.1017/S1092852925100527

Vishal Kumar Gautam, Tapas Kumar Aich, Amil Hayat Khan, Sujita Kumar Kar, Ajeet Chaudhury, Umashankar Kushwaha

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引用次数: 0

Abstract

Background: Obsessive-compulsive disorder (OCD) is a significantly disabling and difficult-to-treat psychiatric disorder. Non-invasive neuromodulation techniques like repetitive transcranial magnetic stimulation (rTMS) have been increasingly used in the management of OCD. This study aimed to compare the efficacy of early augmentation with low-frequency rTMS (LF-rTMS) and continuous theta burst stimulation (cTBS) in improving psychopathology in OCD patients.

Methods: The study design was a parallel-group, double-blind, randomized clinical trial. The study recruited 46 OCD patients who were randomly allocated to receive either LF-rTMS or cTBS (23 patients in each group) following the computer-generated random table method. All participants were rated on YBOCS, HAM-A, and HAM-D at baseline and third week and sixth weeks. These patients received a total of 15 sessions of LF-rTMS or cTBS stimulation once daily for 5 consecutive days in a week for 3 consecutive weeks over the right dorso-lateral pre-frontal cortex (DLPFC) area.

Results: There was a statistically significant improvement in the total YBOCS score for both the LF-rTMS group and the cTBS group at the end of the third and sixth week when compared with their baseline scores. However, there was no statistically significant difference between the 2 groups in terms of the improvement in the total YBOCS score, as well as the total scores for the HAM-A and HAM-D during the follow-up periods.

Conclusion: The study results suggest that both LF-rTMS and cTBS were equally effective in managing OCD patients as an early augmentation strategy.

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针对右侧DLPFC的低频rTMS与连续θ脉冲刺激作为早期增强治疗强迫症的短期疗效：一项随机临床研究。

背景：强迫症（Obsessive-compulsive disorder， OCD）是一种严重致残且难以治疗的精神疾病。重复经颅磁刺激（rTMS）等非侵入性神经调节技术已越来越多地用于强迫症的治疗。本研究旨在比较低频rTMS （LF-rTMS）和持续θ波爆发刺激（cTBS）早期增强治疗对强迫症患者精神病理的改善效果。方法：采用平行组、双盲、随机临床试验。该研究招募了46名强迫症患者，他们按照计算机生成的随机表法随机分配接受LF-rTMS或cTBS（每组23名患者）。在基线、第三周和第六周对所有参与者的YBOCS、HAM-A和HAM-D进行评分。这些患者共接受15次LF-rTMS或cTBS刺激，每天一次，连续5天，一周，连续3周，对右侧背外侧前额叶皮层（DLPFC）区域进行刺激。结果：与基线评分相比，LF-rTMS组和cTBS组在第3周和第6周末的YBOCS总评分有统计学意义上的显著改善。但两组在YBOCS总分、HAM-A总分、HAM-D总分的改善方面，随访期间差异均无统计学意义。结论：研究结果表明，LF-rTMS和cTBS作为一种早期增强策略在治疗强迫症患者方面同样有效。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

CNS Spectrums 医学-精神病学

CiteScore

6.20

自引率

6.10%

发文量

239

审稿时长

>12 weeks

期刊介绍： CNS Spectrums covers all aspects of the clinical neurosciences, neurotherapeutics, and neuropsychopharmacology, particularly those pertinent to the clinician and clinical investigator. The journal features focused, in-depth reviews, perspectives, and original research articles. New therapeutics of all types in psychiatry, mental health, and neurology are emphasized, especially first in man studies, proof of concept studies, and translational basic neuroscience studies. Subject coverage spans the full spectrum of neuropsychiatry, focusing on those crossing traditional boundaries between neurology and psychiatry.