Is avocado beneficial for lipid profiles? An umbrella review of systematic reviews and meta-analyses

IF 2.6 Q3 NUTRITION & DIETETICS

Clinical nutrition ESPEN Pub Date : 2025-08-26 DOI:10.1016/j.clnesp.2025.08.019

Bruno M. Candeloro , Sandra M. Barbalho , Lucas Fornari Laurindo , Rodrigo D. Raimundo , Beatriz L. Stevanato , Maria C.B. Assumpção , Estela M.D. Casangel , Edson H. Ito , Matheus C. Barros , Andrey A. Porto , David M. Garner , Vitor E. Valenti

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Abstract

Background and aims

Avocado is rich in monounsaturated fats, fiber, and phytochemicals and has been linked to favorable lipid and cardiometabolic outcomes. This review synthesized evidence from systematic reviews and meta-analyses on avocado consumption and its effects on cardiovascular risk factors.

Methods

A systematic search was conducted in EMBASE, MEDLINE/PubMed, Scopus, Web of Science, LILACS, CINAHL, and the Cochrane Library for reviews published up to June 2024. Eligible studies examined the impact of avocado on lipid profiles, including total cholesterol (TC), triglycerides (TG), low-density lipoprotein cholesterol (LDL-c), and high-density lipoprotein cholesterol (HDL-c). Study quality was assessed using PRISMA 2020, AMSTAR 2, and GRADE.

Results

Eight reviews met inclusion criteria. In individuals with dyslipidemia, avocado intake was associated with reductions in LDL-c (−9.4 to −17 mg/dL) and TC. Effects on HDL-c and TG (30–500 g/day) were inconsistent. Modest improvements in blood pressure were observed in hypertensive individuals. Among overweight and diabetic populations, reductions in fasting insulin and HbA1c were reported, with no significant changes in fasting glucose or BMI.

Conclusion

Avocado intake may benefit individuals with dyslipidemia by lowering LDL-c and TC. However, inconsistent findings for HDL-c and TG and methodological limitations highlight the need for standardized, long-term trials.

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牛油果对血脂有益吗？综述系统评价和元分析。

背景和目的：鳄梨富含单不饱和脂肪、纤维和植物化学物质，与有利的脂质和心脏代谢结果有关。本综述综合了关于牛油果消费及其对心血管危险因素影响的系统综述和荟萃分析的证据。方法：系统检索EMBASE、MEDLINE/PubMed、Scopus、Web of Science、LILACS、CINAHL和Cochrane Library，检索截止到2024年6月发表的综述。合格的研究检查了鳄梨对脂质谱的影响，包括总胆固醇（TC）、甘油三酯（TG）、低密度脂蛋白胆固醇（LDL-c）和高密度脂蛋白胆固醇（HDL-c）。采用PRISMA 2020、AMSTAR 2和GRADE评估研究质量。结果：8篇综述符合纳入标准。在血脂异常的个体中，鳄梨摄入量与LDL-c（-9.4至-17毫克/分升）和TC的降低有关。对HDL-c和TG （30-500 g/天）的影响不一致。高血压患者血压略有改善。据报道，在超重和糖尿病人群中，空腹胰岛素和HbA1c降低，空腹血糖或BMI无显著变化。结论：摄入鳄梨可通过降低LDL-c和TC对血脂异常患者有益。然而，关于HDL-c和TG的不一致的发现和方法学的局限性突出了标准化、长期试验的必要性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical nutrition ESPEN NUTRITION & DIETETICS-

CiteScore

4.90

自引率

3.30%

发文量

512

期刊介绍： Clinical Nutrition ESPEN is an electronic-only journal and is an official publication of the European Society for Clinical Nutrition and Metabolism (ESPEN). Nutrition and nutritional care have gained wide clinical and scientific interest during the past decades. The increasing knowledge of metabolic disturbances and nutritional assessment in chronic and acute diseases has stimulated rapid advances in design, development and clinical application of nutritional support. The aims of ESPEN are to encourage the rapid diffusion of knowledge and its application in the field of clinical nutrition and metabolism. Published bimonthly, Clinical Nutrition ESPEN focuses on publishing articles on the relationship between nutrition and disease in the setting of basic science and clinical practice. Clinical Nutrition ESPEN is available to all members of ESPEN and to all subscribers of Clinical Nutrition.