Prevalence of undiagnosed stage 3 chronic kidney disease in the Tabari Cohort: a population-based study.

IF 2.4 4区医学 Q2 UROLOGY & NEPHROLOGY

BMC Nephrology Pub Date : 2025-08-21 DOI:10.1186/s12882-025-04383-x

Mahmood Moosazadeh, Farhad Gholami, Pedram Ebrahimnejad, Alireza Rafiei, Maryam Khazaee-Pool, Mahdi Abastabar, Fatemeh Mardanshah, Motahareh Kheradmand

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Abstract

Background: Chronic kidney disease (CKD) is a well-established public health concern worldwide. Considering the asymptomatic nature of early-stage CKD and its importance, we aimed to investigate the prevalence of undiagnosed stage 3 CKD in a large-scale, population-based cohort study.

Methods: In this cross-sectional study, data collected during the enrollment phase of the Tabari Cohort Study (TCS) were utilized. Between June 2015 and November 2017, 10,255 men and women aged 35-70 years were enrolled. CKD was determined based on the estimated glomerular filtration rate (eGFR). The Modification of Diet in Renal Disease (MDRD) equation, utilizing serum creatinine, was used to calculate eGFR. In the present study, participants with 30 ≤ GFR < 60 mL/min/1.73 m² were considered to have stage 3 CKD, and undiagnosed stage 3 CKD was defined as those unaware of CKD at enrollment but had an eGFR between 30 and 60 mL/min/1.73 m². Chi-square tests and univariate and multivariate logistic regression analyses were used to analyze the data.

Results: Out of 10,255 TCS participants, 25.6% (N = 2,630) had stage 3 CKD (30 ≤ eGFR < 60 mL/min/1.73 m²), with 98.1% (N = 2,579) being unaware of their disease. Multivariate logistic regression results showed that the risk of undiagnosed stage 3 CKD was significantly lower in mountainous residents (OR: 0.30, 95% CI: 0.13-0.73, P = 0.008) and participants with hypertension (OR: 0.35, 95% CI: 0.18-0.66, P = 0.001), diabetes (OR: 0.52, 95% CI: 0.29-0.95, P = 0.032), and cardiovascular disease (OR: 0.44, 95% CI: 0.23-0.82, P = 0.010) compared to urban residents and those without hypertension, diabetes, and cardiovascular diseases, respectively.

Conclusion: The present study demonstrated a substantially high prevalence of undiagnosed stage 3 CKD. Urban residency and the absence of medical history of hypertension, diabetes, or cardiovascular disease were predictive factors of undiagnosed stage 3 CKD.

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Tabari队列中未确诊的3期慢性肾病患病率：一项基于人群的研究

背景：慢性肾脏疾病（CKD）是世界范围内公认的公共卫生问题。考虑到早期CKD的无症状性及其重要性，我们的目的是在一项大规模、基于人群的队列研究中调查未确诊的3期CKD的患病率。方法：在本横断面研究中，使用Tabari队列研究（TCS）入组阶段收集的数据。在2015年6月至2017年11月期间，10,255名年龄在35-70岁之间的男性和女性被招募。CKD是根据肾小球滤过率（eGFR）来确定的。利用血清肌酐，采用肾脏疾病饮食修正（MDRD）方程计算eGFR。结果：在10255名TCS参与者中，25.6% （N = 2630）患有3期CKD（30≤eGFR）。结论：本研究显示未确诊的3期CKD的患病率相当高。城市居住和没有高血压、糖尿病或心血管疾病病史是未确诊的3期CKD的预测因素。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

BMC Nephrology UROLOGY & NEPHROLOGY-

CiteScore

4.30

自引率

0.00%

发文量

375

审稿时长

3-8 weeks

期刊介绍： BMC Nephrology is an open access journal publishing original peer-reviewed research articles in all aspects of the prevention, diagnosis and management of kidney and associated disorders, as well as related molecular genetics, pathophysiology, and epidemiology.