A Common Cause of ADHD and Bipolar Disorder (BD)

IF 4.5 2区医学 Q1 CLINICAL NEUROLOGY

Bipolar Disorders Pub Date : 2025-09-01 DOI:10.1111/bdi.70057

Rabinovitch Avinoam, Rabinovitch Revital, Braunstein Doron, Smolik Ella, Biton Yaacov

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引用次数: 0

Abstract

Objectives

Bipolar and ADHD are two diseases that exhibit similar traits but at different levels of severity. Understanding this behavior can help treatment of these disorders.

Method

We hypothesize that there is a common partial genetic cause for both attention-deficit/hyperactivity disorder (ADHD) and bipolar disorders (BD), which is the reversal function of the dopamine neurotransporter DAT gate (see Figure 1) into an efflux mode. We analyze the dopamine chemistry in the neuron synapse under this assumption.

Results

The difference between ADHD and BD phenotypes is due either to the dopamine receptor (D2R) operation or to the threshold levels of the dopamine homeostatic control and the intensity of its operation.

Significance

The common cause of the two disorders could explain the frequent phenomenon of ADHD symptoms preceding BD beginning and the high comorbidity between these disorders.

Abstract Image

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ADHD和双相情感障碍（BD）的常见原因。

目的：双相情感障碍和注意力缺陷多动症是两种表现出相似特征但严重程度不同的疾病。了解这种行为有助于治疗这些疾病。方法：我们假设注意缺陷/多动障碍（ADHD）和双相情感障碍（BD）存在一个共同的部分遗传原因，即多巴胺神经转运体DAT门（见图1）进入外排模式的逆转功能。我们在这个假设下分析了神经元突触中的多巴胺化学。结果：ADHD和BD的表型差异可能与多巴胺受体（D2R）的运作有关，也可能与多巴胺稳态控制的阈值水平及其运作强度有关。意义：两种障碍的共同病因可以解释ADHD症状在BD发病前的频繁现象以及两种障碍之间的高合并症。

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来源期刊

Bipolar Disorders 医学-精神病学

CiteScore

8.20

自引率

7.40%

发文量

审稿时长

6-12 weeks

期刊介绍： Bipolar Disorders is an international journal that publishes all research of relevance for the basic mechanisms, clinical aspects, or treatment of bipolar disorders and related illnesses. It intends to provide a single international outlet for new research in this area and covers research in the following areas: biochemistry physiology neuropsychopharmacology neuroanatomy neuropathology genetics brain imaging epidemiology phenomenology clinical aspects and therapeutics of bipolar disorders Bipolar Disorders also contains papers that form the development of new therapeutic strategies for these disorders as well as papers on the topics of schizoaffective disorders, and depressive disorders as these can be cyclic disorders with areas of overlap with bipolar disorders. The journal will consider for publication submissions within the domain of: Perspectives, Research Articles, Correspondence, Clinical Corner, and Reflections. Within these there are a number of types of articles: invited editorials, debates, review articles, original articles, commentaries, letters to the editors, clinical conundrums, clinical curiosities, clinical care, and musings.