Evaluating Causal Effects of Gut Microbiome on Bipolar Disorder.

IF 4.5 2区医学 Q1 CLINICAL NEUROLOGY

Bipolar Disorders Pub Date : 2025-09-01 DOI:10.1111/bdi.70063

Qian Zhao, Hongbao Cao, Ancha Baranova, Fuquan Zhang

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引用次数: 0

Abstract

Background: Previous studies have shown that gut microbiome dysbiosis has pathogenic significance in the development of bipolar disorder (BD), but the direct causal relationship remains unclear. We aimed to investigate this potential correlation.

Methods: Using a two-sample Mendelian randomization (TSMR) analysis, we examined the potential causal effects of gut microbiota on BD. Summary results for gut microbiota were derived from two large genome-wide association studies (GWAS) on gut microbiota: the MibioGen consortium (N = 18,340) and the Dutch Microbiome Project (N = 8208), as well as one GWAS summary result for BD (N = 413,466).

Results: Our TSMR analysis revealed that the levels of 12 taxa were associated with a reduced risk of BD. These included the phylum Bacteroidetes, its class Bacteroidia, its order Bacteroidales, its species Parabacteroides johnsonii and Paraprevotella unclassified, and genus Faecalibacterium (OR: 0.85 ~ 0.96, p ≤ 0.043). Conversely, 11 gut bacterial taxa were linked to an increased risk of BD. These comprised the class Betaproteobacteria, its order Burkholderiales, and its family Sutterellaceae (OR: 1.06 ~ 1.25, p ≤ 0.049).

Conclusions: Our study further identifies a genetic link between BD and gut microbiota. The causal effects of certain gut microbiota on BD may bring potential clinical benefits and provide a new paradigm for the prevention and treatment of BD.

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评估肠道微生物组对双相情感障碍的因果影响。

背景：既往研究表明，肠道菌群失调在双相情感障碍（BD）的发展中具有致病意义，但其直接因果关系尚不清楚。我们的目的是调查这种潜在的相关性。方法：采用双样本孟德尔随机化（TSMR）分析，研究肠道微生物群对BD的潜在因果影响。肠道微生物群的总结结果来自两项关于肠道微生物群的大型全基因组关联研究（GWAS）： MibioGen联盟（N = 18,340）和荷兰微生物组计划（N = 8208），以及一项关于BD的GWAS总结结果（N = 413,466）。结果：TSMR分析显示，12个类群的水平与BD风险降低相关，包括拟杆菌门、拟杆菌纲、拟杆菌目、拟杆菌属和拟杆菌属（OR: 0.85 ~ 0.96, p≤0.043）。相反，11个肠道细菌分类群与BD风险增加有关，这些细菌包括Betaproteobacteria纲、Burkholderiales目和Sutterellaceae科（OR: 1.06 ~ 1.25, p≤0.049）。结论：我们的研究进一步确定了双相障碍和肠道微生物群之间的遗传联系。某些肠道菌群与双相障碍的因果关系可能带来潜在的临床益处，并为双相障碍的预防和治疗提供新的范例。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Bipolar Disorders 医学-精神病学

CiteScore

8.20

自引率

7.40%

发文量

审稿时长

6-12 weeks

期刊介绍： Bipolar Disorders is an international journal that publishes all research of relevance for the basic mechanisms, clinical aspects, or treatment of bipolar disorders and related illnesses. It intends to provide a single international outlet for new research in this area and covers research in the following areas: biochemistry physiology neuropsychopharmacology neuroanatomy neuropathology genetics brain imaging epidemiology phenomenology clinical aspects and therapeutics of bipolar disorders Bipolar Disorders also contains papers that form the development of new therapeutic strategies for these disorders as well as papers on the topics of schizoaffective disorders, and depressive disorders as these can be cyclic disorders with areas of overlap with bipolar disorders. The journal will consider for publication submissions within the domain of: Perspectives, Research Articles, Correspondence, Clinical Corner, and Reflections. Within these there are a number of types of articles: invited editorials, debates, review articles, original articles, commentaries, letters to the editors, clinical conundrums, clinical curiosities, clinical care, and musings.