The interplay between circadian rhythms and aging: molecular mechanisms and therapeutic strategies.

IF 4.1 4区医学 Q1 GERIATRICS & GERONTOLOGY

Biogerontology Pub Date : 2025-08-27 DOI:10.1007/s10522-025-10301-3

Prashant Dhaka, Neha, Risabh Kumar, Chowdhury Mobaswar Hossain, Suhel Parvez

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Abstract

Circadian rhythms are essential biological systems operating on a 24-h cycle, playing a crucial role in regulating sleep, cognitive function, immune responses, and hormone secretion. This review explores the intricate relationship between circadian rhythms and aging, with a focus on the underlying molecular mechanisms. It discusses age-related changes in sleep patterns and the role of circadian disruption in the progression of neurodegenerative diseases such as Parkinson's and Alzheimer's. Special attention is given to the core CLOCK genes, including BMAL1 and Per2, and their regulatory influence on these processes. The review also highlights the impact of circadian misalignment on metabolic disorders, particularly obesity, diabetes, and cardiovascular disease. Emerging therapeutic strategies targeting circadian pathways-ranging from pharmacological agents to lifestyle modifications-are presented as promising approaches to support healthy aging. This review provides the deeper understanding of how aging affects circadian regulation may pave the way for targeted interventions aimed at extending lifespan and enhancing overall quality of life.

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昼夜节律与衰老之间的相互作用：分子机制和治疗策略。

昼夜节律是一个以24小时为周期运行的基本生物系统，在调节睡眠、认知功能、免疫反应和激素分泌方面起着至关重要的作用。这篇综述探讨了昼夜节律与衰老之间的复杂关系，重点是潜在的分子机制。它讨论了与年龄相关的睡眠模式变化，以及昼夜节律中断在帕金森病和阿尔茨海默病等神经退行性疾病进展中的作用。特别关注核心CLOCK基因，包括BMAL1和Per2，以及它们对这些过程的调节作用。该综述还强调了昼夜节律失调对代谢紊乱的影响，特别是肥胖、糖尿病和心血管疾病。新兴的针对昼夜节律途径的治疗策略——从药理学到生活方式的改变——被认为是支持健康老龄化的有希望的方法。这篇综述提供了对衰老如何影响昼夜节律调节的更深层次的理解，可能为旨在延长寿命和提高整体生活质量的有针对性的干预铺平道路。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Biogerontology 医学-老年医学

CiteScore

8.00

自引率

4.40%

发文量

审稿时长

>12 weeks

期刊介绍： The journal Biogerontology offers a platform for research which aims primarily at achieving healthy old age accompanied by improved longevity. The focus is on efforts to understand, prevent, cure or minimize age-related impairments. Biogerontology provides a peer-reviewed forum for publishing original research data, new ideas and discussions on modulating the aging process by physical, chemical and biological means, including transgenic and knockout organisms; cell culture systems to develop new approaches and health care products for maintaining or recovering the lost biochemical functions; immunology, autoimmunity and infection in aging; vertebrates, invertebrates, micro-organisms and plants for experimental studies on genetic determinants of aging and longevity; biodemography and theoretical models linking aging and survival kinetics.