Gut microbiome and metabolome analysis reveal the alleviating effect of naringenin on duodenal damage in Ningdu yellow chickens caused by heat stress.

IF 2.2 2区农林科学 Q1 VETERINARY SCIENCES

Avian Pathology Pub Date : 2025-09-12 DOI:10.1080/03079457.2025.2549360

Siting Lin, Yan Shi, Jing Liu, Jingyan Luo, Ke Liao, Ping Liu, Xiaona Gao

引用次数: 0

Abstract

Research highlights: Metabolomics and 16S rRNA were used to explore the mitigating effect of naringenin on heat stress.Naringenin relieves heat stress through specific metabolic pathways.Changes in gut microbiota caused by naringenin and heat stress may affect host metabolism.

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肠道微生物组学和代谢组学分析显示柚皮素对宁都黄鸡热应激引起的十二指肠损伤有缓解作用。

热应激（HS）是农业发展面临的主要挑战。肠道健康对于维持机体的整体健康状态至关重要。柚皮素（Naringenin, Nar）是一种天然类黄酮化合物，在治疗一系列疾病方面已显示出相当大的治疗潜力。本研究旨在通过分析肠道微生物组和代谢组来阐明HS对十二指肠肠道完整性的影响以及Nar对这种影响的缓解作用。结果表明，HS对宁都黄鸡肠道抗氧化功能和肠道屏障造成损伤，添加Nar可逆转这一结果，十二指肠通透性得到修复。16S rRNA测序显示，热应激导致有益细菌丰度大幅下降，包括Akkermansia和Lactobacillus。研究发现，Nar可以改变肠道微生物群的组成，从而阻碍条件致病菌（如幽门螺杆菌）的增殖。此外，代谢组学KEGG分析显示，Nar通过调节血清代谢，主要通过ABC转运蛋白途径改善宁都黄鸡热应激状态。相关分析显示，肠道菌群与代谢物之间存在统计学上显著的相关性。本研究结果表明，Nar可减轻HS对宁都黄鸡肠道的损害，其作用与Nar对肠道菌群组成和代谢的影响密切相关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Avian Pathology 农林科学-兽医学

CiteScore

4.50

自引率

10.70%

发文量

审稿时长

1 months

期刊介绍： Avian Pathology is the official journal of the World Veterinary Poultry Association and, since its first publication in 1972, has been a leading international journal for poultry disease scientists. It publishes material relevant to the entire field of infectious and non-infectious diseases of poultry and other birds. Accepted manuscripts will contribute novel data of interest to an international readership and will add significantly to knowledge and understanding of diseases, old or new. Subject areas include pathology, diagnosis, detection and characterisation of pathogens, infections of possible zoonotic importance, epidemiology, innate and immune responses, vaccines, gene sequences, genetics in relation to disease and physiological and biochemical changes in response to disease. First and subsequent reports of well-recognized diseases within a country are not acceptable unless they also include substantial new information about the disease or pathogen. Manuscripts on wild or pet birds should describe disease or pathogens in a significant number of birds, recognizing/suggesting serious potential impact on that species or that the disease or pathogen is of demonstrable relevance to poultry. Manuscripts on food-borne microorganisms acquired during or after processing, and those that catalogue the occurrence or properties of microorganisms, are unlikely to be considered for publication in the absence of data linking them to avian disease.