[Morpho-functional features of the endometrium in uterine leiomyoma before and after embolization of the uterine arteries].

Q4 Medicine

Arkhiv patologii Pub Date : 2025-01-01 DOI:10.17116/patol20258704113

M A Kudimova, L M Mikhaleva, I A Krasnova, V G Breusenko, I A Esipova, S A Mikhalev, N A Gracheva

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引用次数: 0

Abstract

The question of the degree of influence of uterine artery embolization (UAE) on fertility is open. It is important to evaluate the pathomorphological structure and functional activity of the endometrium, the disruption of which can lead to infertility.

Objective: To study morpho-functional changes in the endometrium of patients with uterine fibroids before and after UAE.

Material and methods:

116 patients were divided into 2 groups depending on the type of the leading fibroid node: 1^st - 54 patients examined with uterine fibroid (UF) types 2, 2-5, 3, 2^nd - 62 patients observed with UM types 4, 5, 6.

The comparison group - 30 healthy women. Aspiration biopsy of the endometrium was performed in the middle stage of the secretory phase before and 6-12 months after UAE. The percentage and maturity of pinopodes, the expression level of estrogen (ER), progesterone (PR) receptors in the glands, endometrial stroma, inflammatory markers (CD56+, CD138+) were determined.

Results: The negative impact of UF on the morpho-functional state of the endometrium was determined. Changes were more pronounced in patients of 1^st group. Stroma indices before and after UAE corresponded to comparison group in most patients. After UAE, the number of mature pinopodes decreased in 1^st group, but not in 2^nd group. ER and PR expression levels in the glandular component decreased in all patients, being consistently higher in 1^st group. An increase in proinflammatory markers was observed only in 1^st group.

Conclusion: UF and UAE can disturb morpho-functional state of the endometrium. The impact assessment should be made taking into account the topographic and anatomical location of the myomatous node.

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子宫动脉栓塞前后子宫平滑肌瘤子宫内膜的形态功能特征。

子宫动脉栓塞术（UAE）对生育的影响程度是一个开放性的问题。评估子宫内膜的病理形态结构和功能活动是很重要的，子宫内膜的破坏可能导致不孕。目的：探讨子宫肌瘤患者UAE前后子宫内膜形态功能的变化。材料与方法：116例患者根据前导肌瘤结类型分为2组：1 ~ 54例为子宫肌瘤（UF） 2、2 ~ 5、3型，2 ~ 62例为子宫肌瘤（UM） 4、5、6型。对照组是30名健康女性。子宫内膜穿刺活检于UAE术前和术后6-12个月的分泌期中期进行。测定小足的百分率、成熟度、腺体中雌激素（ER）、孕酮（PR）受体的表达水平、子宫内膜基质、炎症标志物（CD56+、CD138+）。结果：确定UF对子宫内膜形态功能状态的负面影响。第一组患者的变化更为明显。大多数患者UAE前后基质指数与对照组相当。UAE后，第1组成熟pinopod数量减少，第2组没有。所有患者的腺成分中ER和PR表达水平均下降，第一组持续升高。促炎标志物仅在第一组出现升高。结论：UF和UAE可干扰子宫内膜形态功能状态。影响评估应考虑到肌瘤结的地形和解剖位置。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Arkhiv patologii Medicine-Pathology and Forensic Medicine

CiteScore

0.90

自引率

0.00%

发文量

期刊介绍： The journal deals with original investigations on pressing problems of general pathology and pathologic anatomy, newest research methods, major issues of the theory and practice as well as problems of experimental, comparative and geographic pathology. To inform readers latest achievements of Russian and foreign medicine the journal regularly publishes editorial and survey articles, reviews of the most interesting Russian and foreign books on pathologic anatomy, new data on modern methods of investigation (histochemistry, electron microscopy, autoradiography, etc.), about problems of teaching, articles on the history of pathological anatomy development both in Russia and abroad.