Advances in Capsaicin-Based Nanocarriers: Bridging Mechanistic Insights with Therapeutic Potential and Clinical Outcomes.

IF 1.7 4区医学 Q4 BIOCHEMICAL RESEARCH METHODS

Assay and drug development technologies Pub Date : 2025-09-03 DOI:10.1177/1540658X251366755

Kiran Patil, Meghanath B Shete, Tulshidas Patil, Harshada Mahajan, Tejas Mahajan, Nilakshi Maind, Rohan Mehta, Yogeeta Agrawal, Sameer Goyal, Abdulla Sherikar

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引用次数: 0

Abstract

Capsaicin (CAP), a bioactive compound from chili peppers, possesses a wide range of therapeutic properties, including antiobesity, anticancer, anti-inflammatory, analgesic, and cardioprotective effects. However, its clinical application has been limited due to poor aqueous solubility, low bioavailability, rapid metabolism, and potential side effects with high doses. Recent advancements in nanotechnology have addressed these challenges by enhancing CAP's solubility, stability, and targeted delivery through innovative nanoformulations. This review provides an in-depth analysis of various nanocarrier systems such as solid lipid nanoparticles, nanostructured lipid carriers, liposomes, polymeric nanoparticles, nanoemulsions, and nanocrystals, all of which have demonstrated improved therapeutic efficacy of CAP in preclinical studies. These nanoformulations not only protect CAP from degradation but also enable controlled release, reduce side effects, and improve patient compliance. The therapeutic potential of CAP-loaded nanocarriers has been investigated in a variety of diseases, including cancer, neurodegenerative disorders, and chronic pain, with promising results. This review highlights the latest innovations in CAP nanotechnology and discusses the future directions for clinical applications, paving the way for more effective CAP-based therapies in modern medicine.

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基于辣椒素的纳米载体的研究进展：连接机理与治疗潜力和临床结果。

辣椒素（Capsaicin， CAP）是一种从辣椒中提取的生物活性化合物，具有广泛的治疗特性，包括抗肥胖、抗癌、抗炎、镇痛和心脏保护作用。但其水溶性差、生物利用度低、代谢快、大剂量时有潜在的副作用，限制了其临床应用。纳米技术的最新进展通过创新的纳米配方提高了CAP的溶解度、稳定性和靶向递送，解决了这些挑战。这篇综述深入分析了各种纳米载体系统，如固体脂质纳米颗粒、纳米结构脂质载体、脂质体、聚合物纳米颗粒、纳米乳液和纳米晶体，所有这些都在临床前研究中证明了CAP的治疗效果。这些纳米配方不仅可以防止CAP降解，还可以控制释放，减少副作用，并提高患者的依从性。负载cap的纳米载体的治疗潜力已被研究用于多种疾病，包括癌症、神经退行性疾病和慢性疼痛，并取得了可喜的结果。本文综述了CAP纳米技术的最新创新，并讨论了未来的临床应用方向，为现代医学中更有效的基于CAP的治疗铺平了道路。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Assay and drug development technologies 医学-生化研究方法

CiteScore

3.60

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： ASSAY and Drug Development Technologies provides access to novel techniques and robust tools that enable critical advances in early-stage screening. This research published in the Journal leads to important therapeutics and platforms for drug discovery and development. This reputable peer-reviewed journal features original papers application-oriented technology reviews, topical issues on novel and burgeoning areas of research, and reports in methodology and technology application. ASSAY and Drug Development Technologies coverage includes: -Assay design, target development, and high-throughput technologies- Hit to Lead optimization and medicinal chemistry through preclinical candidate selection- Lab automation, sample management, bioinformatics, data mining, virtual screening, and data analysis- Approaches to assays configured for gene families, inherited, and infectious diseases- Assays and strategies for adapting model organisms to drug discovery- The use of stem cells as models of disease- Translation of phenotypic outputs to target identification- Exploration and mechanistic studies of the technical basis for assay and screening artifacts