Dual-functional Anti-hPSMAEC domain nanocapsules for targeted inhibition of prostate tumor growth

IF 8.1 2区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Apoptosis Pub Date : 2025-08-21 DOI:10.1007/s10495-025-02163-4

Heng Yang, Jian He, Yujun Chen, Xiaochen Zhou, Xiaofeng Cheng, Zhenhao Zeng, Min Zhou, Gongxian Wang

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引用次数: 0

Abstract

Addressing prostate cancer, particularly in its aggressive forms, poses challenges that call for innovative treatment modalities. Our research focuses on developing a nanotechnological solution to enhance targeted cancer therapy. We have synthesized advanced nanocapsules embedded with indocyanine green (ICG) and conjugated with the Anti-hPSMA^{EC domain} to improve specificity towards prostate cancer cells. These nanocapsules are engineered to perform dual-mode phototherapy through photothermal and photodynamic mechanisms. In vitro experiments demonstrated the nanocapsules effectively target and induce apoptosis in prostate cancer cells upon exposure to near-infrared light. Furthermore, in vivo assessments in murine models revealed excellent tumor localization and a substantial reduction in tumor volume with minimal impact on healthy tissues. This innovative approach underscores the potential of nanotechnology to transform the therapeutic landscape of prostate cancer by achieving precise targeting and reducing systemic side effects. Such nanocapsule systems’ continued development and refinement may substantially improve clinical outcomes and provide promising therapeutic strategies for treating complex cancers.

Graphical abstract

APCI nanoparticles for sensitive tumor imaging andenhanced PTT & in vivo PDT. (A) Schematic design of APCI for targeted cancer cell delivery; (B) visualization and therapy of orthotopic and metastatic prostate cancer.

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双功能抗hpsmaec结构域纳米胶囊靶向抑制前列腺肿瘤生长

治疗前列腺癌，特别是其侵袭性形式，提出了需要创新治疗方式的挑战。我们的研究重点是开发一种纳米技术解决方案，以增强靶向癌症治疗。我们已经合成了吲哚菁绿（ICG）包埋和结合抗hpsmaec结构域的先进纳米胶囊，以提高对前列腺癌细胞的特异性。这些纳米胶囊被设计成通过光热和光动力机制进行双模光疗。体外实验表明，纳米胶囊在近红外光照射下可有效靶向并诱导前列腺癌细胞凋亡。此外，在小鼠模型中的体内评估显示了良好的肿瘤定位和肿瘤体积的大幅减少，对健康组织的影响最小。这种创新的方法强调了纳米技术通过实现精确靶向和减少全身副作用来改变前列腺癌治疗前景的潜力。这种纳米胶囊系统的持续发展和完善可能会大大改善临床结果，并为治疗复杂癌症提供有希望的治疗策略。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Apoptosis 生物-生化与分子生物学

CiteScore

9.10

自引率

4.20%

发文量

审稿时长

1 months

期刊介绍： Apoptosis, a monthly international peer-reviewed journal, focuses on the rapid publication of innovative investigations into programmed cell death. The journal aims to stimulate research on the mechanisms and role of apoptosis in various human diseases, such as cancer, autoimmune disease, viral infection, AIDS, cardiovascular disease, neurodegenerative disorders, osteoporosis, and aging. The Editor-In-Chief acknowledges the importance of advancing clinical therapies for apoptosis-related diseases. Apoptosis considers Original Articles, Reviews, Short Communications, Letters to the Editor, and Book Reviews for publication.