{"title":"Global and regional molecular epidemiology of HIV-1 among men who have sex with men: a systematic review and meta-analysis.","authors":"Ruiyu Li, Yin Gao, Ting Song, Nan Li, Rui Deng, Feng Jiao, Chaofang Yan, Ying Chen","doi":"10.1186/s12981-025-00776-y","DOIUrl":null,"url":null,"abstract":"<p><strong>Objectives: </strong>The diversity of HIV-1 genotypes among Men who have sex with men (MSM) globally has changed considerably. The purpose of this study to assess the global prevalence of HIV-1 genotypes among MSM.</p><p><strong>Methods: </strong>PubMed, Embase, Scopus, and Web of Science were systematically searched to identify the articles. Pooled prevalence of HIV-1 genotypes was calculated and subgroup analyses were performed to examine the prevalence estimates across time and locations.</p><p><strong>Results: </strong>A total of 95 studies were included in the final analysis, including 84,622 successfully genotyped samples. The predominant strains were CRF01_AE (34.46%), subtype B (31.16%), and CRF07_BC (24.72%). In subgroup analyses, Subtype B and C showed a declining trend over the years. However, CRF07_BC exhibited a consistent year-on-year increase, while CRF01_AE experienced a slight reduction after 2018. Notably, both subtypes currently account for more than 35% of the total. In addition, the distribution of HIV-1 subtypes in this population shown a clear regional distribution. Regionally, subtype B predominated in Latin America and Europe, CRF01_AE and CRF07_BC in Asia and China, while subtype C and CRF02_AG were dominant in Africa and the Middle East.</p><p><strong>Conclusions: </strong>Global and regions MSM HIV-1 subtypes are becoming more complex over time and the prevalence of recombinant viruses is increasing. Ongoing and effective surveillance of the global and regional molecular epidemiology of HIV-1 in MSM is critical for developing targeted preventive control measures against HIV.</p>","PeriodicalId":7503,"journal":{"name":"AIDS Research and Therapy","volume":"22 1","pages":"86"},"PeriodicalIF":2.5000,"publicationDate":"2025-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12398045/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"AIDS Research and Therapy","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1186/s12981-025-00776-y","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"INFECTIOUS DISEASES","Score":null,"Total":0}
引用次数: 0
Abstract
Objectives: The diversity of HIV-1 genotypes among Men who have sex with men (MSM) globally has changed considerably. The purpose of this study to assess the global prevalence of HIV-1 genotypes among MSM.
Methods: PubMed, Embase, Scopus, and Web of Science were systematically searched to identify the articles. Pooled prevalence of HIV-1 genotypes was calculated and subgroup analyses were performed to examine the prevalence estimates across time and locations.
Results: A total of 95 studies were included in the final analysis, including 84,622 successfully genotyped samples. The predominant strains were CRF01_AE (34.46%), subtype B (31.16%), and CRF07_BC (24.72%). In subgroup analyses, Subtype B and C showed a declining trend over the years. However, CRF07_BC exhibited a consistent year-on-year increase, while CRF01_AE experienced a slight reduction after 2018. Notably, both subtypes currently account for more than 35% of the total. In addition, the distribution of HIV-1 subtypes in this population shown a clear regional distribution. Regionally, subtype B predominated in Latin America and Europe, CRF01_AE and CRF07_BC in Asia and China, while subtype C and CRF02_AG were dominant in Africa and the Middle East.
Conclusions: Global and regions MSM HIV-1 subtypes are becoming more complex over time and the prevalence of recombinant viruses is increasing. Ongoing and effective surveillance of the global and regional molecular epidemiology of HIV-1 in MSM is critical for developing targeted preventive control measures against HIV.
目的：全球男男性行为者（MSM）中HIV-1基因型的多样性发生了很大变化。本研究的目的是评估全球HIV-1基因型在男男性行为者中的流行情况。方法：系统检索PubMed、Embase、Scopus、Web of Science等文献。计算HIV-1基因型的总患病率，并进行亚组分析，以检查不同时间和地点的患病率估计。结果：最终分析共纳入95项研究，包括84,622个成功基因分型的样本。优势菌株为CRF01_AE（34.46%）、B亚型（31.16%）和CRF07_BC（24.72%）。在亚组分析中，B和C亚型呈逐年下降趋势。然而，CRF07_BC在2018年之后呈现出持续的同比增长，而CRF01_AE则略有下降。值得注意的是，这两种亚型目前占总数的35%以上。此外，HIV-1亚型在该人群中的分布具有明显的区域分布。从区域上看，B亚型主要分布在拉丁美洲和欧洲，CRF01_AE和CRF07_BC主要分布在亚洲和中国，而C亚型和CRF02_AG主要分布在非洲和中东。结论：随着时间的推移，全球和地区MSM HIV-1亚型变得越来越复杂，重组病毒的流行率也在增加。持续有效地监测全球和区域HIV-1在男男性行为者中的分子流行病学对制定有针对性的艾滋病毒预防控制措施至关重要。
期刊介绍：
AIDS Research and Therapy publishes articles on basic science, translational, clinical, social, epidemiological, behavioral and educational sciences articles focused on the treatment and prevention of HIV/AIDS, and the search for the cure. The Journal publishes articles on novel and developing treatment strategies for AIDS as well as on the outcomes of established treatment strategies. Original research articles on animal models that form an essential part of the AIDS treatment research are also considered
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