Preliminary evidence for perceived rapid alcohol tolerance growth as a risk factor for problematic alcohol use.

IF 2.2 4区 医学 Q3 SUBSTANCE ABUSE
Frances L Wang, Brooke S G Molina, Sarah L Pedersen, Deepa A Thomas
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引用次数: 0

Abstract

Background: Preclinical research with animals suggests that a propensity to more rapidly adapt to the effects of alcohol could be an important neurobiological difference underlying alcohol use disorder (AUD). Research translating this work to humans is scarce. We tested whether adults' self-perceptions of rapidly developing alcohol tolerance following the onset of regular drinking was associated with increased risk of problematic alcohol use (using scores that excluded tolerance items), while controlling for several potentially important confounders.

Methods: Adults who reported current heavy drinking completed an online survey (N = 160; M(SD) = 32.24(9.30) years old; 56.3% Black, 43.8% White; 55% Female, 45% Male). Participants reported the extent to which "my tolerance to alcohol seemed to build up very quickly once I started drinking frequently." Initial subjective response was measured as the number of drinks to experience alcohol effects during the first five drinking experiences and acquired tolerance as the difference between current and initial subjective response. Participants reported on alcohol consequences and dependence symptoms using modified DSM-5 criteria (i.e. problematic alcohol use), past year alcohol consumption, and demographic characteristics.

Results: Hierarchical linear regression showed that perceived rapid tolerance growth was uniquely associated with problematic alcohol use (excluding tolerance symptoms) after controlling for initial subjective response, acquired tolerance, DSM-5-related tolerance, alcohol consumption, race, sex, and age.

Conclusions: Individuals who reported experiencing rapid tolerance growth when they started regularly drinking showed increased risk for problematic alcohol use. Future prospective research on this topic is warranted and could help uncover a novel risk factor for AUD.

初步证据表明,酒精耐受性的快速增长是问题酒精使用的危险因素。
背景:动物临床前研究表明,更快适应酒精影响的倾向可能是酒精使用障碍(AUD)背后重要的神经生物学差异。将这项工作转化为人类的研究很少。我们测试了成年人在开始定期饮酒后迅速发展的酒精耐受性的自我认知是否与问题酒精使用的风险增加有关(使用排除耐受性项目的评分),同时控制了几个潜在的重要混杂因素。方法:报告当前重度饮酒的成年人完成在线调查(N = 160; M(SD) = 32.24(9.30)岁;56.3%黑人,43.8%白人;55%女性,45%男性)。参与者报告说,“一旦我开始频繁饮酒,我对酒精的耐受性似乎很快就会增强。”最初的主观反应被测量为在前五次饮酒经历中体验酒精效应的饮料数量,获得的耐受性被测量为当前和最初的主观反应之间的差异。参与者使用修改后的DSM-5标准(即问题性酒精使用)、过去一年的酒精消费量和人口统计学特征报告酒精后果和依赖症状。结果:层次线性回归显示,在控制了初始主观反应、获得性耐受性、dsm -5相关耐受性、酒精消耗、种族、性别和年龄后,感知到的耐受性快速增长与问题酒精使用(不包括耐受性症状)唯一相关。结论:那些开始定期饮酒后耐受性迅速增长的人出现问题性饮酒的风险增加。未来对这一主题的前瞻性研究是必要的,可能有助于发现澳元的一个新的风险因素。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Alcohol and alcoholism
Alcohol and alcoholism 医学-药物滥用
CiteScore
4.70
自引率
3.60%
发文量
62
审稿时长
4-8 weeks
期刊介绍: About the Journal Alcohol and Alcoholism publishes papers on the biomedical, psychological, and sociological aspects of alcoholism and alcohol research, provided that they make a new and significant contribution to knowledge in the field. Papers include new results obtained experimentally, descriptions of new experimental (including clinical) methods of importance to the field of alcohol research and treatment, or new interpretations of existing results. Theoretical contributions are considered equally with papers dealing with experimental work provided that such theoretical contributions are not of a largely speculative or philosophical nature.
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