{"title":"Circular RNAs as Biomarkers in the Diagnosis of Human Diseases.","authors":"Selçuk Özdemir","doi":"10.1007/978-981-96-9428-0_14","DOIUrl":null,"url":null,"abstract":"<p><p>Circular RNAs (circRNAs) are a class of noncoding RNAs (ncRNAs), which has the formation of reverse splicing of mRNAs. Interest in their regulatory function has recently been increasing. The most important features are its stability between species, its high abundance, and its evolutionary conservation. As a cellular function, circular RNAs are involved in transcriptional modulation and splicing from miRNA and protein sponges. In addition, they are differentially expressed in pathological conditions occurring in diseases, creating their potential as biomarkers. Resistance to RNases makes circular RNAs a less invasive biomarker. Studies on human tumors and other diseases have confirmed the regulatory role and expression profiles of circular RNAs in disease progenesis. This article discusses in detail the properties, functions, and mechanisms of action of circRNAs in human diseases. We also discuss the possibility of using circRNAs as potential therapeutic targets and biomarkers for human diseases.</p>","PeriodicalId":7270,"journal":{"name":"Advances in experimental medicine and biology","volume":"1485 ","pages":"211-226"},"PeriodicalIF":0.0000,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Advances in experimental medicine and biology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1007/978-981-96-9428-0_14","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"Biochemistry, Genetics and Molecular Biology","Score":null,"Total":0}
引用次数: 0
Abstract
Circular RNAs (circRNAs) are a class of noncoding RNAs (ncRNAs), which has the formation of reverse splicing of mRNAs. Interest in their regulatory function has recently been increasing. The most important features are its stability between species, its high abundance, and its evolutionary conservation. As a cellular function, circular RNAs are involved in transcriptional modulation and splicing from miRNA and protein sponges. In addition, they are differentially expressed in pathological conditions occurring in diseases, creating their potential as biomarkers. Resistance to RNases makes circular RNAs a less invasive biomarker. Studies on human tumors and other diseases have confirmed the regulatory role and expression profiles of circular RNAs in disease progenesis. This article discusses in detail the properties, functions, and mechanisms of action of circRNAs in human diseases. We also discuss the possibility of using circRNAs as potential therapeutic targets and biomarkers for human diseases.
期刊介绍：
Advances in Experimental Medicine and Biology provides a platform for scientific contributions in the main disciplines of the biomedicine and the life sciences. This series publishes thematic volumes on contemporary research in the areas of microbiology, immunology, neurosciences, biochemistry, biomedical engineering, genetics, physiology, and cancer research. Covering emerging topics and techniques in basic and clinical science, it brings together clinicians and researchers from various fields.
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