Mechanical Interactions Impact the Functions of Immune Cells and Their Application in Immunoengineering

IF 2.6 4区 医学 Q2 PHARMACOLOGY & PHARMACY
Yu-Chang Chen, Nghi M. Tran, Kyle H. Vining
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引用次数: 0

Abstract

Immune cells experience a wide range of modes and magnitudes of mechanical forces as they infiltrate tissues and physically interact with other cells. Biophysical forces influence cell phenotypes through mechanosensing of the cytoskeleton, cell adhesion, catch and slip bonds, and mechanically gated ion channels. As a result, different mechanical environments impact the function and expression of immune cell receptors, which subsequently affects local and systemic immune responses. Mechanical coupling of immune cell receptors can be exploited in immunoengineering applications such as adoptive cell transfer and artificial antigen-presenting cells through biomaterial systems with tunable mechanical properties that regulate receptor expression and cell activation. This review covers immune cell receptors in the adaptive and innate immune system that respond to mechanical forces and their potential to be applied for advancing current immunotherapies.

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机械相互作用影响免疫细胞的功能及其在免疫工程中的应用。
免疫细胞在渗透组织并与其他细胞发生物理相互作用时,会经历各种模式和大小的机械力。生物物理力通过细胞骨架的机械传感、细胞粘附、捕获和滑动键以及机械门控离子通道影响细胞表型。因此,不同的机械环境影响免疫细胞受体的功能和表达,进而影响局部和全身免疫反应。免疫细胞受体的机械偶联可用于免疫工程应用,如过继细胞转移和人工抗原呈递细胞,通过具有可调节机械特性的生物材料系统来调节受体表达和细胞活化。本文综述了适应性免疫和先天免疫系统中对机械力作出反应的免疫细胞受体及其在推进当前免疫治疗方面的应用潜力。
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来源期刊
Advanced Therapeutics
Advanced Therapeutics Pharmacology, Toxicology and Pharmaceutics-Pharmaceutical Science
CiteScore
7.10
自引率
2.20%
发文量
130
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