Iron‑catalyzed divergent synthesis of carbazole-based di-/triarylmethanes.

IF 3.8 2区化学 Q2 CHEMISTRY, APPLIED

Molecular Diversity Pub Date : 2025-08-20 DOI:10.1007/s11030-025-11286-4

Yi-Jun Jiang, Hao-Lan Hu, Yu-Dan Niu, Meng-Yuan Li, Peng Chen

引用次数: 0

Abstract

A simple and efficient iron-catalyzed divergent dehydrative coupling of carbazoles and benzylic alcohols has been developed. By using different iron catalysts, mono-substituted or di-substituted carbazole-based di-/triarylmethanes, some of which are bioactive and potential pharmaceutical molecules or potential molecular precursors for optoelectronic materials, were synthesized site-selectively from the same set of reactants. This method was demonstrated with 68 examples, in up to 98% yield and with broad functional group compatibilities.

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铁催化咔唑基二/三芳基甲烷的发散合成。

建立了一种简单高效的铁催化咔唑与苯醇的分散脱水偶联反应。通过使用不同的铁催化剂，从同一组反应物中选择性地合成了单取代或双取代咔唑基二/三芳基甲烷，其中一些是生物活性和潜在的药物分子或光电材料的潜在分子前体。该方法经68个样品验证，收率高达98%，具有广泛的官能团相容性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Molecular Diversity 化学-化学综合

CiteScore

7.30

自引率

7.90%

发文量

219

审稿时长

2.7 months

期刊介绍： Molecular Diversity is a new publication forum for the rapid publication of refereed papers dedicated to describing the development, application and theory of molecular diversity and combinatorial chemistry in basic and applied research and drug discovery. The journal publishes both short and full papers, perspectives, news and reviews dealing with all aspects of the generation of molecular diversity, application of diversity for screening against alternative targets of all types (biological, biophysical, technological), analysis of results obtained and their application in various scientific disciplines/approaches including: combinatorial chemistry and parallel synthesis; small molecule libraries; microwave synthesis; flow synthesis; fluorous synthesis; diversity oriented synthesis (DOS); nanoreactors; click chemistry; multiplex technologies; fragment- and ligand-based design; structure/function/SAR; computational chemistry and molecular design; chemoinformatics; screening techniques and screening interfaces; analytical and purification methods; robotics, automation and miniaturization; targeted libraries; display libraries; peptides and peptoids; proteins; oligonucleotides; carbohydrates; natural diversity; new methods of library formulation and deconvolution; directed evolution, origin of life and recombination; search techniques, landscapes, random chemistry and more;