Sustainable and renewable approaches in biomaterial-based integrated dried urine sampling/solid-phase extraction devices for drugs and metabolites: challenges, bioanalytical applications, and future directions.

IF 3.8 2区 化学 Q1 BIOCHEMICAL RESEARCH METHODS
Sohan G Jawarkar, Pinaki Sengupta
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引用次数: 0

Abstract

Urine samples are gaining increasing importance as preferred biological matrices in bioanalytical studies due to their non-invasive collection, abundance, and ability to reflect systemic metabolism. However, conventional urine sampling and storage methods face significant challenges, especially in resource-limited areas where transportation and preservation infrastructure are inadequate. Traditional methods of liquid urine collection require refrigeration to prevent analyte degradation, making long-term storage and global sample transport costly and impractical. Biomaterial-based integrated dried urine sampling (DUS) devices integrate both storage and extraction into a single-step process, significantly enhancing efficiency and reliability. The porous sorbent is designed with a high surface area and tailored molecular binding capacity, ensuring the selective adsorption of target metabolites while minimizing matrix effects. Its structure allows for rapid drying and ambient-temperature storage, eliminating the need for cold-chain logistics. This feature is particularly beneficial for field studies and resource-constrained settings where maintaining refrigeration is impractical. Biomaterial-based DUS devices could be cost-effective and customizable and enable long-term stabilization of urinary metabolites. By reducing drying times, enhancing analyte recovery, and improving storage conditions, this technology enhances the feasibility of large-scale bioanalytical studies, therapeutic drug monitoring, and clinical diagnostics. Furthermore, its ability to selectively extract metabolites streamlines laboratory workflows and improves overall analytical precision. Porous biomaterial-based DUS devices could present a transformative, sustainable, and renewable solution for bioanalysis. By addressing the critical issues of sample stability, extraction efficiency, and cost-effectiveness, this approach has the potential to revolutionize metabolomics research, personalized medicine, and biomarker discovery in both clinical and research settings.

基于生物材料的药物和代谢物集成干燥尿液取样/固相萃取装置的可持续和可再生方法:挑战、生物分析应用和未来方向。
由于尿液样本的非侵入性收集、丰富度和反映全身代谢的能力,其作为首选生物基质在生物分析研究中越来越重要。然而,传统的尿液采样和储存方法面临着重大挑战,特别是在资源有限的地区,运输和保存基础设施不足。传统的液体尿液收集方法需要冷藏以防止分析物降解,这使得长期储存和全球样本运输成本高昂且不切实际。基于生物材料的集成干燥尿液采样(DUS)设备将存储和提取集成到一个单步过程中,显着提高了效率和可靠性。多孔吸附剂设计具有高表面积和定制的分子结合能力,确保选择性吸附目标代谢物,同时最大限度地减少基质效应。它的结构允许快速干燥和常温储存,消除了冷链物流的需要。这一特点特别有利于现场研究和资源有限的设置,维持制冷是不切实际的。基于生物材料的DUS装置具有成本效益和可定制性,并且能够长期稳定尿液代谢物。通过减少干燥时间,提高分析物回收率,改善储存条件,该技术提高了大规模生物分析研究,治疗药物监测和临床诊断的可行性。此外,其选择性提取代谢物的能力简化了实验室工作流程,提高了整体分析精度。基于多孔生物材料的DUS装置可以为生物分析提供一种变革性的、可持续的和可再生的解决方案。通过解决样品稳定性、提取效率和成本效益的关键问题,这种方法有可能在临床和研究环境中彻底改变代谢组学研究、个性化医疗和生物标志物发现。
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来源期刊
CiteScore
8.00
自引率
4.70%
发文量
638
审稿时长
2.1 months
期刊介绍: Analytical and Bioanalytical Chemistry’s mission is the rapid publication of excellent and high-impact research articles on fundamental and applied topics of analytical and bioanalytical measurement science. Its scope is broad, and ranges from novel measurement platforms and their characterization to multidisciplinary approaches that effectively address important scientific problems. The Editors encourage submissions presenting innovative analytical research in concept, instrumentation, methods, and/or applications, including: mass spectrometry, spectroscopy, and electroanalysis; advanced separations; analytical strategies in “-omics” and imaging, bioanalysis, and sampling; miniaturized devices, medical diagnostics, sensors; analytical characterization of nano- and biomaterials; chemometrics and advanced data analysis.
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