Skye Shepherd, Weinan Liu, Seemesh Bhaskar, Brian T Cunningham
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引用次数: 0
Abstract
The unique optical interaction of species such as nanomaterials, proteins, viruses, antibodies, microRNA, and exosomes with the one-dimensional grating-based photonic crystals (PCs) has been leveraged in their detection using photonic crystal absorption microscopy (PRAM). While the principle and fundamental mechanism of such interfacial interactions are well delineated using wavelength and intensity modulations associated with the guided-mode resonance (GMR) of the PC, the effect of nano-assemblies in place of nanoparticles (NPs) has not been reported previously. In this work, the fundamental limitations observed with pristine NPs are overcome through the use of tunable AuNP assemblies synthesized via adiabatic cooling technology, where tunable nano-assemblies are obtained by subjecting the respective NPs to - 196 °C. Moreover, the higher contrast rendered by magneto-plasmonic, Fe3O4-Au hybrid nano-assemblies vis-à-vis metallic AuNP assemblies is corroborated with COMSOL Multiphysics simulations using electric and magnetic field hotspots. The high-contrast digital resolution enabled by magneto-plasmonic hybrid nano-assemblies, on account of synergistic coupling between the GMR of the underlying PC, delocalized Bragg, and localized Mie plasmons of dielectric-metal nano-assemblies, demonstrated excellent performance for microRNA-375-3p detection, opening a new window to explore hybrids of tunable "permittivity + permeability" as active probes in the design and development of microscopy-based biosensing modalities.
期刊介绍:
Analytical and Bioanalytical Chemistry’s mission is the rapid publication of excellent and high-impact research articles on fundamental and applied topics of analytical and bioanalytical measurement science. Its scope is broad, and ranges from novel measurement platforms and their characterization to multidisciplinary approaches that effectively address important scientific problems. The Editors encourage submissions presenting innovative analytical research in concept, instrumentation, methods, and/or applications, including: mass spectrometry, spectroscopy, and electroanalysis; advanced separations; analytical strategies in “-omics” and imaging, bioanalysis, and sampling; miniaturized devices, medical diagnostics, sensors; analytical characterization of nano- and biomaterials; chemometrics and advanced data analysis.