Global landscape and translational trajectories of flavonoid-based wound-healing research

Abstract

Flavonoids have antioxidant, anti-inflammatory, and antimicrobial properties, making them promising agents in wound healing. This scientometric analysis examined 3416 articles (2005–2024) from the Web of Science using CiteSpace, VOSviewer, and R to map global trends, collaborations, mechanisms, and translational pathways. PubMed was also searched to examine patterns in clinical research, encompassing both randomized controlled trials (|RCTs) and observational studies. China contributed 25.8% of publications, followed by India (14.8%) and the USA (10.5%). Research focus has shifted from phytochemistry to clinically oriented studies, with quercetin, hesperidin, luteolin, diosmetin, and naringenin emerging as leading compounds linked to nanoformulations and hydrogel composites. These results provide a quantitative roadmap for advancing flavonoid-based wound therapeutics toward clinical application.