Harnessing viral footprints in circulating free DNA (cfDNA) for early cancer detection: A focus on liquid-biopsy-based screening.

IF 4.7 2区医学 Q1 ONCOLOGY

International Journal of Cancer Pub Date : 2025-09-03 DOI:10.1002/ijc.70121

Richard Donkor Amponsah, Emmanuel Addai Gyabaah, Moro Amidu, Zhao Cheng, Fazlur Rahman Talukdar

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引用次数: 0

Abstract

Viral infections play a significant role in cancer development, making detecting viral signatures a promising approach for early cancer diagnosis. Circulating free DNA (cfDNA), released into the bloodstream by tumors and other cells, has emerged as a powerful biomarker for non-invasive cancer screening. This review explores the potential of cfDNA in detecting virus-associated cancers through the analysis of viral footprints. It provides a comprehensive overview of the biological mechanisms underlying cfDNA release, the role of oncogenic viruses in cancer progression, and the unique viral markers that can be traced within cfDNA. By leveraging viral genetic material, cfDNA analysis offers transformative potential for the early detection of virus-driven malignancies. Highlighting its clinical relevance, this review discusses how cfDNA-based viral biomarker screening could significantly enhance cancer monitoring, improve prognosis accuracy, and pave the way for innovative, non-invasive diagnostic tools and personalized cancer management strategies.

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利用循环游离DNA （cfDNA）中的病毒足迹进行早期癌症检测：以液体活检为基础的筛查。

病毒感染在癌症发展中起着重要作用，因此检测病毒特征是早期癌症诊断的一种有希望的方法。循环游离DNA （cfDNA）由肿瘤和其他细胞释放到血液中，已成为非侵入性癌症筛查的强大生物标志物。这篇综述探讨了cfDNA通过分析病毒足迹来检测病毒相关癌症的潜力。它全面概述了cfDNA释放的生物学机制，致癌病毒在癌症进展中的作用，以及可以在cfDNA中追踪的独特病毒标记物。通过利用病毒遗传物质，cfDNA分析为病毒驱动的恶性肿瘤的早期检测提供了变革性的潜力。强调其临床意义，本综述讨论了基于cfdna的病毒生物标志物筛选如何显著增强癌症监测，提高预后准确性，并为创新的非侵入性诊断工具和个性化癌症管理策略铺平道路。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International Journal of Cancer 医学-肿瘤学

CiteScore

13.40

自引率

3.10%

发文量

460

审稿时长

2 months

期刊介绍： The International Journal of Cancer (IJC) is the official journal of the Union for International Cancer Control—UICC; it appears twice a month. IJC invites submission of manuscripts under a broad scope of topics relevant to experimental and clinical cancer research and publishes original Research Articles and Short Reports under the following categories: -Cancer Epidemiology- Cancer Genetics and Epigenetics- Infectious Causes of Cancer- Innovative Tools and Methods- Molecular Cancer Biology- Tumor Immunology and Microenvironment- Tumor Markers and Signatures- Cancer Therapy and Prevention