Quantum Osteoimmunology: A Paradigm Shift in Understanding and Influencing Bone-Immune Crosstalk.

IF 3.4 4区 医学 Q2 CHEMISTRY, MEDICINAL
ChemMedChem Pub Date : 2025-08-27 DOI:10.1002/cmdc.202500307
Rachel Wei Li, Sara Alzaanin, Zongyou Yin, Paul N Smith
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引用次数: 0

Abstract

Despite significant advancesin osteoimmunology, the mechanistic underpinnings of immune-skeletal crosstalk remain insufficiently characterized, particularly at the molecular and submolecular scales. The present article introduces quantum osteoimmunology as a novel field of research exploring how quantum mechanical phenomena, such as coherence, tunneling, entanglement, and wavefunction superposition, may influence osteoimmune signaling dynamics. It argues that the current deterministic, temporally linear models of immune activation may overlook the probabilistic and non-linear nature of molecular events governed by quantum principles. Integrating quantum principles into osteoimmune research could offer new explanatory models for unresolved questions in bone-immune physiology and pathology. In parallel, the unique photophysical characteristics of quantum nanomaterials, such as size-tunable emission spectra, high quantum yields, and photostability, present unprecedented opportunities for high-resolution biomarker detection, enabling real-time, ultrasensitive diagnostics for osteoimmune pathologies. Moreover, these materials exhibit significant potential for the development of traceable, precision-targeted therapeutic delivery systems, as well as for high-resolution in vitro and in vivo bioimaging applications. Ultimately, quantum mechanics holds the potential to revolutionize osteoimmunology-conceptually, by reshaping one's understanding of immune-skeletal interactions at the subatomic level; and practically, by driving innovations in diagnostics, targeted therapeutics, and real-time molecular imaging.

量子骨免疫学:理解和影响骨免疫串扰的范式转变。
尽管骨免疫学取得了重大进展,但免疫-骨骼串扰的机制基础仍然没有充分表征,特别是在分子和亚分子尺度上。本文介绍量子骨免疫学作为一个新的研究领域,探索量子力学现象,如相干、隧道、纠缠和波函数叠加,如何影响骨免疫信号动力学。它认为,目前免疫激活的确定性,时间线性模型可能忽略了量子原理支配的分子事件的概率和非线性性质。将量子原理整合到骨免疫研究中可以为骨免疫生理学和病理学中尚未解决的问题提供新的解释模型。同时,量子纳米材料独特的光物理特性,如尺寸可调的发射光谱、高量子产率和光稳定性,为高分辨率生物标志物检测提供了前所未有的机会,使骨免疫病理的实时、超灵敏诊断成为可能。此外,这些材料在开发可追溯的、精确靶向的治疗递送系统以及高分辨率的体外和体内生物成像应用方面表现出巨大的潜力。最终,量子力学有可能在概念上彻底改变骨免疫学,通过重塑人们对亚原子水平上免疫-骨骼相互作用的理解;实际上,通过推动诊断、靶向治疗和实时分子成像方面的创新。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
ChemMedChem
ChemMedChem 医学-药学
CiteScore
6.70
自引率
2.90%
发文量
280
审稿时长
1 months
期刊介绍: Quality research. Outstanding publications. With an impact factor of 3.124 (2019), ChemMedChem is a top journal for research at the interface of chemistry, biology and medicine. It is published on behalf of Chemistry Europe, an association of 16 European chemical societies. ChemMedChem publishes primary as well as critical secondary and tertiary information from authors across and for the world. Its mission is to integrate the wide and flourishing field of medicinal and pharmaceutical sciences, ranging from drug design and discovery to drug development and delivery, from molecular modeling to combinatorial chemistry, from target validation to lead generation and ADMET studies. ChemMedChem typically covers topics on small molecules, therapeutic macromolecules, peptides, peptidomimetics, and aptamers, protein-drug conjugates, nucleic acid therapies, and beginning 2017, nanomedicine, particularly 1) targeted nanodelivery, 2) theranostic nanoparticles, and 3) nanodrugs. Contents ChemMedChem publishes an attractive mixture of: Full Papers and Communications Reviews and Minireviews Patent Reviews Highlights and Concepts Book and Multimedia Reviews.
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