Multifunctional Responsive Gas-Releasing Metal Organic Framework Nanoplatform for Tumor Therapy Application.

IF 3.4 4区 医学 Q2 CHEMISTRY, MEDICINAL
ChemMedChem Pub Date : 2025-08-28 DOI:10.1002/cmdc.202500602
Yue Meng, Jing Lu, Xiangwei Liu, Ruixuan Liu, Ding Dai, Yuan Sun, Tiedong Sun
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引用次数: 0

Abstract

Gas therapy (GT), which regulates the tumor microenvironment by releasing therapeutic gas molecules (e.g., O2, NO), has taken an innovative direction in tumor therapy. However, conventional gas-releasing molecules (GRMs) suffer from core problems such as uncontrollable release, poor targeting, and insufficient stability. To address these challenges, nanoplatforms represented by metal-organic frameworks (MOFs) offer an innovative solution. MOFs, with their high specific surface area, tunable porosity, and abundant active sites, are able to significantly enhance the storage and release efficiency of gases. In particular, the high specific surface area and porosity of MOFs enable efficient loading of therapeutic gases and targeted release of gases through precise regulation of porosity; their abundant active sites enhance the stability and controllability of gas release. This review focuses on the preparation and modulation of MOF, systematically describes the advantages of MOF-based GRM nanoplatforms in the efficient loading and responsive release of therapeutic gases, such as oxygen (O2), nitric oxide (NO), and hydrogen (H2), and summarizes their recent progress in the field of GT for tumor treatment. Finally, the challenges and future perspectives of GT- and MOF-based GRM nanoplatforms are discussed to provide more effective and safer therapeutic strategies for clinical applications.

多功能响应气体释放金属有机框架纳米平台在肿瘤治疗中的应用。
气体疗法(Gas therapy, GT)通过释放治疗气体分子(如O2、NO)调节肿瘤微环境,是肿瘤治疗的一个创新方向。然而,传统的气体释放分子(GRMs)存在释放不可控、靶向性差、稳定性不足等核心问题。为了应对这些挑战,以金属有机框架(mof)为代表的纳米平台提供了一种创新的解决方案。mof具有高比表面积、可调孔隙度和丰富的活性位点,能够显著提高气体的储存和释放效率。特别是,mof的高比表面积和孔隙率使其能够通过精确调节孔隙度来有效加载治疗气体和靶向释放气体;它们丰富的活性位点增强了气体释放的稳定性和可控性。本文综述了MOF的制备和调控,系统介绍了基于MOF的GRM纳米平台在氧气(O2)、一氧化氮(NO)和氢气(H2)等治疗气体的高效加载和响应释放方面的优势,并总结了其在肿瘤治疗领域的最新进展。最后,讨论了基于GT和mof的GRM纳米平台的挑战和未来前景,以期为临床应用提供更有效和更安全的治疗策略。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
ChemMedChem
ChemMedChem 医学-药学
CiteScore
6.70
自引率
2.90%
发文量
280
审稿时长
1 months
期刊介绍: Quality research. Outstanding publications. With an impact factor of 3.124 (2019), ChemMedChem is a top journal for research at the interface of chemistry, biology and medicine. It is published on behalf of Chemistry Europe, an association of 16 European chemical societies. ChemMedChem publishes primary as well as critical secondary and tertiary information from authors across and for the world. Its mission is to integrate the wide and flourishing field of medicinal and pharmaceutical sciences, ranging from drug design and discovery to drug development and delivery, from molecular modeling to combinatorial chemistry, from target validation to lead generation and ADMET studies. ChemMedChem typically covers topics on small molecules, therapeutic macromolecules, peptides, peptidomimetics, and aptamers, protein-drug conjugates, nucleic acid therapies, and beginning 2017, nanomedicine, particularly 1) targeted nanodelivery, 2) theranostic nanoparticles, and 3) nanodrugs. Contents ChemMedChem publishes an attractive mixture of: Full Papers and Communications Reviews and Minireviews Patent Reviews Highlights and Concepts Book and Multimedia Reviews.
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