Even at 100+: Acute Exercise Modulates Inflammatory Pathways in Centenarians

IF 7.1 1区医学 Q1 Biochemistry, Genetics and Molecular Biology

Aging Cell Pub Date : 2025-07-15 DOI:10.1111/acel.70152

Abel Plaza-Florido, Lidia B. Alejo, Inmaculada Pérez-Prieto, Pedro Carrera-Bastos, María Rosado Muñoz, Itziar Pagola Aldazabal, David Barranco-Gil, Alejandro Santos-Lozano, Gabriel Rodríguez-Romo, Natalia Yanguas-Casás, Shlomit Radom-Aizik, Alejandro Lucia, Carmen Fiuza-Luces

引用次数: 0

Abstract

Centenarians exhibit remarkable disease resilience despite chronic low-grade inflammation. We investigated the inflammation-related proteome response to acute exercise in seven centenarians (100–104 years). Exercise downregulated 52 proteins (e.g., TNF, IL10, IL1RN, CCL family members) involved in immune cell trafficking, apoptosis, and cytokine regulation. Even at the extreme end of the lifespan, humans retain molecular responsiveness to exercise, with modulation of inflammation-related pathways.

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即使在100岁以上：急性运动调节百岁老人的炎症途径。

尽管慢性低度炎症，百岁老人仍表现出显著的疾病恢复能力。我们研究了7位百岁老人（100-104岁）急性运动时炎症相关的蛋白质组反应。运动下调了参与免疫细胞运输、凋亡和细胞因子调节的52种蛋白（如TNF、IL10、IL1RN、CCL家族成员）。即使到了生命的最后阶段，人类也会通过调节炎症相关途径，保持对运动的分子反应。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Aging Cell 生物-老年医学

CiteScore

14.40

自引率

2.60%

发文量

212

审稿时长

8 weeks

期刊介绍： Aging Cell, an Open Access journal, delves into fundamental aspects of aging biology. It comprehensively explores geroscience, emphasizing research on the mechanisms underlying the aging process and the connections between aging and age-related diseases.