Traceable nanoparticles with mitochondria-targeting pyruvate-Cu induce cuproptosis for enhanced triple-negative breast cancer therapy in a mouse model.

IF 10.7 2区材料科学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Materials Horizons Pub Date : 2025-09-02 DOI:10.1039/d5mh01047k

Chen Peng, Jiaxin Li, Nan Wang, Xinyue Zhang, Wen Zhang, Zhirui Li, Keyi Zhang, Yangchaowei Ji, Wei He, Yan Li

引用次数: 0

Abstract

We develop pyruvate with good biocompatibility and mitochondria-targeting ability as a copper ionophore (pyruvate-Cu). To further address its drawbacks, traceable nanoparticles are constructed to deliver pyruvate-Cu for triple negative breast cancer (TNBC) treatment. In vitro and in vivo results demonstrate that this work provides an efficient platform for enhanced TNBC therapy.

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可追踪的纳米颗粒与线粒体靶向丙酮酸铜诱导铜增生，以增强三阴性乳腺癌治疗小鼠模型。

我们开发了具有良好生物相容性和线粒体靶向能力的丙酮酸作为铜离子载体（丙酮酸- cu）。为了进一步解决其缺点，构建了可追踪的纳米颗粒来递送丙酮酸-铜用于三阴性乳腺癌（TNBC）的治疗。体外和体内结果表明，这项工作为加强TNBC治疗提供了一个有效的平台。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Materials Horizons CHEMISTRY, MULTIDISCIPLINARY-MATERIALS SCIENCE, MULTIDISCIPLINARY

CiteScore

18.90

自引率

2.30%

发文量

306

审稿时长

1.3 months

期刊介绍： Materials Horizons is a leading journal in materials science that focuses on publishing exceptionally high-quality and innovative research. The journal prioritizes original research that introduces new concepts or ways of thinking, rather than solely reporting technological advancements. However, groundbreaking articles featuring record-breaking material performance may also be published. To be considered for publication, the work must be of significant interest to our community-spanning readership. Starting from 2021, all articles published in Materials Horizons will be indexed in MEDLINE©. The journal publishes various types of articles, including Communications, Reviews, Opinion pieces, Focus articles, and Comments. It serves as a core journal for researchers from academia, government, and industry across all areas of materials research. Materials Horizons is a Transformative Journal and compliant with Plan S. It has an impact factor of 13.3 and is indexed in MEDLINE.