Long-term exposure to low-level nitrogen dioxide and risks of neurodegenerative diseases among middle-aged and older adults in the UK

IF 3.9 3区环境科学与生态学 Q1 CHEMISTRY, ANALYTICAL

Environmental Science: Processes & Impacts Pub Date : 2025-08-26 DOI:10.1039/D5EM00342C

Yujia Bao, Yongxuan Li, Ne Qiang, Yanqiu Zhou, Mike Z. He, Chen Shen, Xiaobei Deng, Jie Yin, Lefei Han and Jinjun Ran

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Abstract

Divergent views remain regarding the health assessment of ambient nitrogen dioxide (NO₂) exposure at low-level concentrations. To fill in some gaps, this study was designed to comprehensively estimate the effects of low-level NO₂ exposure on the brain system. This study included 183 351 participants with ambient NO₂ ≤ 20 μg m⁻³ at baseline from the UK Biobank and analyzed associations of NO₂ exposure with neurodegenerative diseases and brain imaging traits through modeling. The results indicated that among populations exposed to ambient NO₂ ≤ 20 μg m⁻³, an interquartile range (4.7 μg m⁻³) increase in NO₂ exposure was associated with elevated incident risks of Alzheimer's disease (hazard ratio 1.18; 95% confidence interval 1.05, 1.32) and vascular dementia (1.25; 95% confidence interval 1.07, 1.46), respectively. The associations were also observed with specific grey matter and white matter phenotypes. The findings suggest that updating a lower limit for ambient NO₂ may yield significant benefits.

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英国中老年人长期暴露于低水平二氧化氮与神经退行性疾病的风险

关于低浓度环境二氧化氮（NO2）暴露的健康评估，仍然存在不同的观点。为了填补一些空白，本研究旨在全面评估低水平NO2暴露对脑系统的影响。本研究纳入了来自英国生物银行（UK Biobank）的183 351名基线环境NO2≤20 μg m-3的参与者，通过建模分析了NO2暴露与神经退行性疾病和脑成像特征的关系。结果表明，在环境二氧化氮≤20 μg m-3的人群中，二氧化氮暴露的四分位数范围（4.7 μg m-3）增加与阿尔茨海默病（风险比1.18,95%可信区间1.05 ~ 1.32）和血管性痴呆（1.25,95%可信区间1.07 ~ 1.46）的发生率升高相关。这种关联也被观察到与特定的灰质和白质表型有关。研究结果表明，更新环境二氧化氮的下限可能会产生显著的好处。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Environmental Science: Processes & Impacts CHEMISTRY, ANALYTICAL-ENVIRONMENTAL SCIENCES

CiteScore

9.50

自引率

3.60%

发文量

202

审稿时长

1 months

期刊介绍： Environmental Science: Processes & Impacts publishes high quality papers in all areas of the environmental chemical sciences, including chemistry of the air, water, soil and sediment. We welcome studies on the environmental fate and effects of anthropogenic and naturally occurring contaminants, both chemical and microbiological, as well as related natural element cycling processes.