Structure-function relationship of S protein cleavage in cowpea mosaic virus intratumoral immunotherapy

IF 5.7 3区医学 Q1 MATERIALS SCIENCE, BIOMATERIALS

Biomaterials Science Pub Date : 2025-08-26 DOI:10.1039/D5BM00969C

Andrea Simms, Jessica Fernanda Affonso de Oliveira, Narek Minasov, Edward Cedrone, Marina A. Dobrovolskaia and Nicole F. Steinmetz

引用次数: 0

Abstract

Translational studies are underway for cowpea mosaic virus (CPMV) as a candidate for intratumoral immunotherapy. To further strengthen the argument for translation, here we demonstrate that a structural deviation in CPMV's small (S) coat protein does not negatively impact its antitumor efficacy, immune cell uptake, or cytokine profile.

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豇豆花叶病毒瘤内免疫治疗中S蛋白裂解的结构-功能关系。

豇豆花叶病毒（CPMV）作为肿瘤内免疫治疗的候选药物正在进行转化研究。为了进一步加强翻译的论点，我们在这里证明了CPMV小(S)外壳蛋白的结构偏差不会对其抗肿瘤功效、免疫细胞摄取或细胞因子谱产生负面影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Biomaterials Science MATERIALS SCIENCE, BIOMATERIALS-

CiteScore

11.50

自引率

4.50%

发文量

556

期刊介绍： Biomaterials Science is an international high impact journal exploring the science of biomaterials and their translation towards clinical use. Its scope encompasses new concepts in biomaterials design, studies into the interaction of biomaterials with the body, and the use of materials to answer fundamental biological questions.