A Case of Complete Remission Achieved Through Stereotactic Radiotherapy for Isolated Bone Metastasis Following Four Courses of Bleomycin, Etoposide, and Cisplatin Chemotherapy for Testicular Cancer

Q4 Medicine

IJU Case Reports Pub Date : 2025-08-13 DOI:10.1002/iju5.70080

Kentaro Arinami, Gen Kawaguchi, Kozue Ito, Yurie Takizawa, Go Hasegawa, Yohei Ikeda, Noboru Hara, Tsutomu Nishiyama

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Abstract

Introduction

We report a case of nonseminoma germ cell tumor, in which solitary bone metastasis was detected by magnetic resonance imaging (MRI) after systemic chemotherapy, and resolution was achieved with stereotactic radiotherapy.

Case Presentation

A 42-year-old man was diagnosed with right-sided testicular cancer, T1N1M0, and right high orchiectomy was performed. Pathology revealed a mixed germ cell tumor. He received four 3-week courses of chemotherapy (BEP). Although computed tomography showed no new metastases, whole-body MRI revealed a solitary bone metastasis to the left sacrum, and stereotactic radiotherapy of 36.8 Gy/8f was administered to the same area. After radiotherapy, the accumulation in that area disappeared on MRI.

Conclusion

As evidence accumulates, it is likely that whole-body MRI will become a useful observational method for staging and monitoring patients with germ cell tumors. Stereotactic radiotherapy may be used as consolidation therapy for patients with residual masses after systemic therapy.

Abstract Image

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睾丸癌在博来霉素、依托泊苷和顺铂化疗四疗程后，经立体定向放疗治疗孤立性骨转移完全缓解1例

我们报告一例非精原细胞瘤生殖细胞瘤，在全身化疗后通过磁共振成像（MRI）发现孤立性骨转移，并采用立体定向放疗解决。病例介绍一名42岁男性被诊断为右侧睾丸癌T1N1M0，行右侧高位睾丸切除术。病理显示混合性生殖细胞瘤。患者接受4个3周疗程的化疗（BEP）。尽管计算机断层扫描未发现新的转移，但全身MRI显示左侧骶骨有孤立性骨转移，并对同一区域进行了36.8 Gy/8f的立体定向放疗。放射治疗后，该区域的堆积在MRI上消失。结论随着证据的不断积累，全身MRI有可能成为生殖细胞肿瘤分期和监测的一种有用的观察方法。立体定向放疗可作为全身治疗后残余肿块的巩固治疗。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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